昆明医科大学学报2024，Vol.45Issue(3)：151-156,6.DOI:10.12259/j.issn.2095-610X.S20240323
外周血Septin9基因甲基化检测在结直肠腺瘤中的预测价值
Predictive Value of Peripheral Blood Septin9 Gene Methylation Assay in Colorectal Adenoma
摘要
Abstract
Objective To investigate the predictive significance of Septin9 gene methylation(mSEPT9)in peripheral blood in the diagnosis of colorectal adenoma.Methods A total of 52 subjects were included,31 patients with colorectal adenomas were collected as the experimental group in the Department of Pathology and 21 subjects with negative colonoscopy in the gastroenterology outpatient clinic were used as the control group from October 2020 to May 2022.mSEPT9 was detected in the two groups,and the results of CEA level in peripheral blood were collected.All the results were statistically analyzed using the Receiver Operating Characteristic(ROC).Results The area under the curve(area of the ROC:AUC)of mSEPT9detectionto predict the development of adenoma was 0.7205(P<0.05),And the cut-off value(CT value)was 39.55,the corresponding sensitivity was 90.91%and the specificity was 56.67%.The AUC of CEA detection for predicting adenoma was 0.5333(P>0.05).Conclusions The detection of mSEPT9 is better than that of CEA tumor marker detection in peripheral blood for screening colorectal adenomas with good sensitivity and relative specificity.Invasive colonoscopy for people with positive mSEPT9 screening results can be easier to accept by the general population.关键词
Septin9基因/甲基化检测/结直肠腺瘤Key words
Septin9 Gene/Methylation detection/Colorectal adenoma分类
医药卫生引用本文复制引用
邓菊庆,于璐,廖丽琼,杨忠存..外周血Septin9基因甲基化检测在结直肠腺瘤中的预测价值[J].昆明医科大学学报,2024,45(3):151-156,6.基金项目
昆明市卫生健康委员会卫生科研课题项目(2020-01-04-001) （2020-01-04-001）
