昆明医科大学学报2024，Vol.45Issue(3)：180-185,6.DOI:10.12259/j.issn.2095-610X.S20240327
铁死亡在心肌病中的研究进展
Research Progress of Iron Death in Cardiomyopathy
摘要
Abstract
Cardiomyopathy is a group of heterogeneous myocardial diseases with a variety of specific phenotypes that can lead to cardiovascular death or progressive heart failure in severe cases.Because of the severity and complexity of these diseases,the search for new regulatory mechanisms to prevent and treat cardiomyopathy is particularly urgent.Iron death is a form of programmed cell death that differs from other forms of iron dependence and is characterized by the accumulation of iron-dependent lipid peroxides.Studies have shown that iron death can be involved in the occurrence and progression of cardiomyopathy through different signaling pathways.Therefore,targeted regulation of iron death is a new strategy to prevent cardiomyopathy.In this paper,the mechanism of iron death and its important role in cardiomyopathy were reviewed to find the potential relationship between iron death and cardiomyopathy and provide more ideas for the treatment of various cardiomyopathies in the future.关键词
心肌病/铁死亡/氧化应激/铁代谢Key words
Cardiomyopathy/Ferroptosis/Cell death/Iron metabolism分类
医药卫生引用本文复制引用
李威,蒋立虹,马丽晶,陈锐,杨童硕..铁死亡在心肌病中的研究进展[J].昆明医科大学学报,2024,45(3):180-185,6.基金项目
国家自然科学基金资助项目(81960068) （81960068）
云南省科技厅科技计划项目(202101AY070001-265) （202101AY070001-265）
