内蒙古民族大学学报（自然科学版）2024，Vol.39Issue(2)：7-15,9.DOI:10.14045/j.cnki.15-1220.2024.02.002
蒙医三种基本体质人群肠道菌群结构差异研究
Study on the Difference of Intestinal Flora Structure among Three Basic Mongolian Medicine Constitution Populations
摘要
Abstract
This study aims to provide a scientific basis for identifying the three fundamental constitutions of Mongolian medicine(MM)and tailoring individualized clinical treatments in Mongolian medicine by comparing the physiological indexes and intestinal flora structure of the three basic MM constitution populations.Firstly,the three kinds of basic MM constitution populations were determined according to the"Classification and Determination Score Sheet of E's Mongolian Medicine Constitutions",and the basic physiological indexes were measured.Second-ly,the Ilumina NovaSeq sequencing method was used to detect 16S rRNA in feces of people with different constitu-tions,and according to the species annotation,the Alpha and Beta diversity and inter-group differences were ana-lyzed,so as to explain the flora differences among different constitutions.Results showed that the BMI of the Bada-gan group significantly exceeded those of the Heyi and aggregated constitution groups(P＜0.05).While the BMI of Xila group significantly lower than those of the other three groups(P＜0.05).The results of Alpha diversity and Be-ta diversity analysis of intestinal flora showed that there were significant differences in microflora structure among the three basic constitution populations and the aggregated constitution population.The results of comparison be-tween different constitution groups showed that the Bacteroidota,Proteobacteria,Megamonas,Escherichia-Shigella,Prevotella,Bacteroides,Faecalibacterium and so on were significantly different in different constitution populations.The differential flora was mainly involved in regulating physiological functions such as drug resistance,fat metabo-lism,carbohydrate metabolism,amino acid metabolism and immune system.This study demonstrates for the first time that there are significant differences in intestinal flora structure among different MM constitution populations,and it is closely related to important physiological functions such as regulating the metabolism of various nutrients,immune function and drug tolerance.The findings provide scientific basis for the scientific determination of physi-cal constitution and clinical individualized medication in Mongolian medicine.关键词
蒙医体质/生理指标/肠道菌群/免疫功能/个体化医疗Key words
Mongolian medicine constitutions/physiological index/intestinal flora/immune function/personal-ized medicine分类
医药卫生引用本文复制引用
阿如热,苏如那,于红珍,白丽,付明海..蒙医三种基本体质人群肠道菌群结构差异研究[J].内蒙古民族大学学报（自然科学版）,2024,39(2):7-15,9.基金项目
内蒙古自治区本科直属高校2019年"双一流"建设专项资金蒙药科研创新团队建设项目(190301) （190301）
