宁夏大学学报（自然科学版）2024，Vol.45Issue(1)：51-54,4.
藏药喉毛花中3个环烯醚萜化合物的提取及其抑菌活性
Extraction of Three Eremophilane Sesquiterpenes from Tibetan Herbal Medicine Comastoma pulmonarium and Their Antibacterial Activity
摘要
Abstract
The chemical constituents of eremophilane sesquiterpenes in the Tibetan medicine Comastoma pul-monarium and their antibacterial activities were studied.Using chromatographic methods such as silica gel,gel,resin materials(MCI-GEL),and RP-HPLC,three eremophilane sesquiterpene compounds were extracted and isolated from the Comastoma pulmonarium-acetone(φ=70%)system.The structures were characterized by UV spectroscopy,infrared spectroscopy,mass spectrometry,and nuclear magnetic resonance spectroscopy.The antibacterial activity of the isolated compounds was assessed using the broth microdilution method.The results showed that the three eremophilane sesquiterpene compounds were identified as(Z)-6-ethoxy-5-ethyli-dene-4,5,6,8-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one(1),swerimilegenins H(2),and swerimile-genins I(3),with compound 1 being a new compound.Compounds 1 to 3 all exhibited certain antibacterial activities.关键词
龙胆科/喉毛花属/喉毛花/环烯醚萜/抑菌活性Key words
gentianaceae/Comastoma(Wettst.)Toyokuni/Comastoma pulmonarium/iridoid/bacteriostatic activity分类
医药卫生引用本文复制引用
郑君娜,黄茹,罗甸,杨新周,胡秋芬,董淼,李银科..藏药喉毛花中3个环烯醚萜化合物的提取及其抑菌活性[J].宁夏大学学报（自然科学版）,2024,45(1):51-54,4.基金项目
国家自然科学基金资助项目(21762050) （21762050）
云南省科技计划基金资助项目(2019HC020) （2019HC020）
