藏药喉毛花中3个环烯醚萜化合物的提取及其抑菌活性OACHSSCDCSTPCD

The chemical constituents of eremophilane sesquiterpenes in the Tibetan medicine Comastoma pul-monarium and their antibacterial activities were studied.Using chromatographic methods such as silica gel,gel,resin materials(MCI-GEL),and RP-HPLC,three eremophilane sesquiterpene compounds were extracted and isolated from the Comastoma pulmonarium-acetone(φ=70%)system.The structures were characterized by UV spectroscopy,infrared spectroscopy,mass spectrometry,and nuclear magnetic resonance spectroscopy.The antibacterial activity of the isolated compounds was assessed using the broth microdilution method.The results showed that the three eremophilane sesquiterpene compounds were identified as(Z)-6-ethoxy-5-ethyli-dene-4,5,6,8-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one(1),swerimilegenins H(2),and swerimile-genins I(3),with compound 1 being a new compound.Compounds 1 to 3 all exhibited certain antibacterial activities.