皮肤性病诊疗学杂志2024，Vol.31Issue(3)：175-179,5.DOI:10.3969/j.issn.1674-8468.2024.03.005
古塞奇尤单抗治疗中重度斑块状银屑病23例临床观察
Clinical observation of guselkumab in the treatment of 23 cases of moderate to severe plaque psoriasis
夏丽晔 1范琳婵 1王为平 1尚智伟1
作者信息
- 1. 河南科技大学临床医学院河南科技大学第一附属医院,河南 洛阳 471003
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy and safety of guselkumab injection in the treatment of moderate to severe plaque psoriasis.Methods Twenty three patients with moder-ate to severe plaque psoriasis were treated with subcutaneous injection of guselkumab at a dose of 100 mg at weeks 0 and 4,followed by once every 8 weeks.The psoriasis lesion area and severity index(PASI)were evaluated at weeks 4 and 12,and adverse reactions were recorded.Results All 23 patients received treatment at least 3 times(0,4,12 weeks).At week 12,23 patients(100％)achieved PASI 75 or above,including PASI 90 in 19 patients(82.61％)and PASI 100 in 10 patients(43.48％).No serious adverse reactions were observed.Conclusions Guselkumab is safe and effective for moderate to severe plaque psoriasis,and can rapidly improve skin lesions.It provides a new treatment option for patients with moderate to severe plaque psoriasis.关键词
银屑病/生物制剂/白介素23/古塞奇尤单抗Key words
psoriasis/biological agents/interleukin-23/guselkumab引用本文复制引用
夏丽晔,范琳婵,王为平,尚智伟..古塞奇尤单抗治疗中重度斑块状银屑病23例临床观察[J].皮肤性病诊疗学杂志,2024,31(3):175-179,5.
