摘要
Abstract
We report a case of small lymphocytic lymphoma with hypersensitive reactions to mosquito bites as the first skin manifestation.A 49-year-old male presented with a 5-year history of repeated swollen and itching on the head and neck region after mosquito bites.The current episode occurred a week ago.The findings of dermatological examination included swollen erythemas cov-ered with millet-to green bean-sized papules and vesicles accompanied with exudation on the right lateral cheek,the right part of posterior neck and right subscapular region.There were lymphade-nopathies behind the right ear,in the lower right jaw,the bilateral neck and armpits,with tender-ness.The histopathology of right cervical lymph node showed destruction of lymph nodes and a large number of small lymphocytes,with uniform morphology,less cytoplasm,inconspicuous nu-cleoli,and few mitotic figures.Immunohistochemistry showed CD20(+),Pax-5(+),CD3(-),CD5(+),CD23(+),Bcl-2(+),Bcl-6(-),CD10(-),Cyclin-D1(-),SOX-11(-),Mum-1(-),CD4(-),CD8(-),CD56(-),Ki-67(30％+).In situ hybridization showed EBER negative.Anti-EBV antibody(EB-VCA-IgG)levels were＞750.0 U/mL.The di-agnoses of chronic lymphocytic leukemia/small lymphocytic lymphoma and hypersensitivity to mos-quito bites were made.The patient was transferred to the hematology department and is currently under follow-up because of no indication for treatment.关键词
小淋巴细胞淋巴瘤/蚊虫叮咬超敏反应/EB病毒/淋巴结肿大Key words
small lymphocytic lymphoma/hypersensitivity to mosquito bites/EB virus/lymphadenectasis
