皮肤性病诊疗学杂志2024，Vol.31Issue(3)：198-202,5.DOI:10.3969/j.issn.1674-8468.2024.03.009
瘦素与银屑病的研究进展
The role of leptin in psoriasis
摘要
Abstract
Psoriasis,a systemic immune-inflammatory disease,is often associated with meta-bolic syndromes such as obesity.As the most classical pro-inflammatory adipokine,leptin has re-ceived persistent attention in psoriasis.Currently,it is generally believed that leptin promotes the development of psoriasis.This article delves into the intricate relationship between leptin and the development of psoriasis,along with its associated metabolic complications.Additionally,the po-tential mechanisms by which leptin operates in the pathological processes of psoriasis,such as im-mune inflammatory activation,epidermal keratinocyte proliferation,differentiation and secretion of proinflammatory factors,and proliferation and dilatation of dermal papillary capillaries,are ex-plored.关键词
银屑病/瘦素/免疫细胞/角质形成细胞/毛细血管Key words
psoriasis/leptin/immune cells/keratinocytes/capillaries引用本文复制引用
陈琳,熊慧,郭庆..瘦素与银屑病的研究进展[J].皮肤性病诊疗学杂志,2024,31(3):198-202,5.基金项目
广东省自然科学基金(2021A1515010069) （2021A1515010069）
广东省医师协会皮肤研究专项课题(20210104) （20210104）
