Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency ca-theter ablationOA北大核心

BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency cath-eter ablation(RFCA). METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an Jiaotong Univer-sity were included in this study.The participants were grouped based on cumulative TyG index values tertiles within 3 months after ablation.Cox regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF recurrence.The predictive value of all risk factors was assessed by receiver operating curve analysis. RESULTS There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence in-creased with increasing cumulative TyG index values tertiles.After adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)= 4.949,95%CI:1.778-13.778,P = 0.002]and the high cumulative TyG index gr-oup(HR = 8.716,95%CI:3.371-22.536,P＜0.001)had a higher risk of AF recurrence than those in the low cumulative TyG ind-ex group.The restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulat-ive TyG index values.When considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)= 0.847,95%CI:0.797-0.897,P＜0.001]. CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after RFCA.Monitoring longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.