昆明医科大学学报2024，Vol.45Issue(3)：7-17,11.DOI:10.12259/j.issn.2095-610X.S20240302
ERK1/2信号通路基因3'UTR多态性与非小细胞肺癌的相关性
Association of Polymorphisms in the 3'UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer
摘要
Abstract
Objective To investigate the association between four single nucleotide polymorphisms(SNP)(rs9340 in MAPK1,rs14804 in NRAS,rs712 and rs7973450 in KRAS)in the 3'UTR of ERK1/2 signaling pathway-related genes and non-small cell lung cancer(NSCLC).Methods A total of 478 NSCLC patients and 480 healthy controls were enrolled in this study.Four SNPs were genotyped by using TaqMan assays.The association between the four SNPs and NSCLC was analyzed.Results The distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the non-small cell squamous cell carcinoma(SCC)group(P = 0.009),suggesting that the G allele of rs9340 may be a protective factor for non-small cell lung squamous cell carcinoma(OR = 0.67,95%CI:0.50～0.91).In addition,in the<50 years age group,the distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the NSCLC group(P = 5.07×10-4),indicating that the G allele of rs9340 may be a protective factor for NSCLC(OR = 0.46,95%CI:0.29～0.72).Conclusion The SNP rs9340 in MAPK1 may be associated with the risk of NSCLC.关键词
非小细胞肺癌/ERK1/2信号通路/单核苷酸多态性/3'UTR/MAPK1Key words
Non-small cell lung cancer/ERK1/2 signaling pathway/SNP/3'UTR/MAPK1分类
医药卫生引用本文复制引用
洪超,向旭东,李盈甫,曹杨,陈雪雅,李帅,邢安灏,林牧,马千里..ERK1/2信号通路基因3'UTR多态性与非小细胞肺癌的相关性[J].昆明医科大学学报,2024,45(3):7-17,11.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202201AY070001-141) （202201AY070001-141）
保山市科技计划项目-2023年医学研究联合专项基金资助项目(2023bskjylms016) （2023bskjylms016）
