昆明医科大学学报2024，Vol.45Issue(3)：30-34,5.DOI:10.12259/j.issn.2095-610X.S20240304
1800MHz电磁辐射暴露对大鼠海马GFAP表达的"窗口效应"
The"Window Effect"Study on the Effect of 1800 MHz Electromagnetic Radiation Irradiation on GFAP Expression in the Hippocampus of Rats
摘要
Abstract
Objective To investigate the effect of electromagnetic wave power density on the expression of glial fibrillary acidic protein(GFAP)in the hippocampus of SD rats under 1800 MHz electromagnetic wave irradiation,and whether it exhibits a"window effect".Methods Ninety-eight 4-week-old SPF-grade SD rats were randomly divided into 14 groups,with 7 rats in each group.Seven groups were exposed groups(frequency:1800 MHz,power densities:0.1 mW/cm2,0.3 mW/cm2,0.5 mW/cm2,0.7 mW/cm2,0.9 mW/cm2,1.0 mW/cm2,1.2 mW/cm2)and corresponding 7 groups were control groups(power density:0 mW/cm2).Exposure was conducted for 12 hours daily for 3 weeks.After exposure,Western Blot was used to detect the expression level of GFAP in the hippocampal tissue,and immunohistochemistry staining was performed to determine the average optical density(MOD)value of GFAP-positive expression products in the DG,CA3,and CA1 regions of the hippocampal tissue,to determine the power density window of GFAP expression in the hippocampus of SD rats under 1800 MHz exposure.Results At power densities of 0.1 mW/cm2 and 0.3 mW/cm2,Western Blot results showed increased expression of GFAP in the rat hippocampus(P<0.05),and immunohistochemistry staining demonstrated increased MOD values of GFAP in the three regions(P<0.05).Conclusion Long-term exposure to 1800 MHz elect-romagnetic radiation has a"window effect"on the expression of GFAP in the DG,CA3,and CA1 regions of the hippocampus in SD rats,with power density windows of 0.1 mW/cm2 and 0.3 mW/cm2.关键词
电磁辐射/神经胶质纤维酸性蛋白(GFAP)/窗口效应/1800MHzKey words
Electromagnetic wave/Glial fibriliary acidic protein(GFAP)/The window effect/1800 MHz分类
医药卫生引用本文复制引用
徐晓霜,熊庆,张媛,武慧欣,和丽梅,木云珍..1800MHz电磁辐射暴露对大鼠海马GFAP表达的"窗口效应"[J].昆明医科大学学报,2024,45(3):30-34,5.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202101AY070001-056) （202101AY070001-056）
