生命科学仪器2023，Vol.21Issue(6)：109-112,4.DOI:10.11967/2023211224
外周血单个核细胞miR-221表达对老年腹腔镜全麻手术患者术后认知功能预测价值
Predictive value of miR-221 expression in peripheral blood mononuclear cells for postoperative cognitive function in elderly patients undergoing laparoscopic general anesthesia
摘要
Abstract
Objective:To investigate the predictive value of microRNA(miR)-221 expression in peripheral blood mononuclear cells for postoperative cognitive function in elderly patients undergoing laparoscopic general anesthe-sia.Methods:A total of 93 elderly patients undergoing laparoscopic general anesthesia surgery in Hengshui Fourth People's Hospital from January 2021 to January 2022 as research subjects,divided disabled group(n=32)and no disabled group(n=61)the barrier-free group according cognitive dysfunction after operation.The MoCA score,miR-221 expression,NSE and S100b protein expressions compared disabled group and no disabled group;ROC curve analyze the predictive value of miR-221 for cognitive impairment;Pearson analyze miR-221 and MoCA score,NSE and S100b protein express correlation.Results:Disabled group MoCA score,relative expression of miR-221,serum NSE and S100b protein levels higher no disabled group(P<0.05).The ROC curve analysis miR-221 had a sensitivity of 87.5%and a specificity of 98.4%for the prediction of cognitive impairment.Pearson analy-sis relative expression of miR-221 linearly negatively correlated with MoCA score,and positively correlated with NSE and S100b protein levels(P<0.05).Conclusion:Elderly patients with laparoscopic general anesthesia expres-sion of miR-221 in patients with postoperative cognitive dysfunction is significantly increased,used as an indicator to predict postoperative cognitive dysfunction.关键词
外周血单个核细胞/微小RNA-221/老年腹腔镜手术/全麻/认知功能Key words
peripheral blood mononuclear cells/microRNA-221/geriatric laparoscopic surgery/general anesthe-sia/cognitive function分类
医药卫生引用本文复制引用
柳永健,齐英花,姜荣强,刘菊,周红荣..外周血单个核细胞miR-221表达对老年腹腔镜全麻手术患者术后认知功能预测价值[J].生命科学仪器,2023,21(6):109-112,4.基金项目
河北省中医药管理局科研计划项目(2019357) （2019357）
