饲料研究2024，Vol.47Issue(4)：92-98,7.DOI:10.13557/j.cnki.issn1002-2813.2024.04.017
金莲花饲用安全性评价
Evaluation of feeding safety of Trollius chinensis
摘要
Abstract
The purpose of the experiment was to explore the feeding safety of Trollius chinensis.Acute toxicity test,genotoxicity test(bacterial reversion mutation test,mammalian erythrocyte micronucleus test,mouse spermatocyte chromosome aberration),and subchronic toxicity test were conducted on Trollius chinensis.The results showed that the median lethal dose(LD50)of Kunming mice was more than 10.0 g/kg·BW.The results of the genotoxicity test showed no mutagenic effect of Trollius chinensis on experimental animals.The results of the rat teratogenicity test showed that there were no toxic signs,no reproductive toxicity,and no teratogenicity in pregnant rats of each dose group.The subchronic toxicity test showed no toxicity and death in rats.There was no significant difference in body weight,weight gain,food intake,food utilization rate,and viscera-body ratio between rats in each dose group and negative control group(P＞0.05).The blood routine,blood biochemistry,urine routine,and other indexes of rats in each group were all in the normal range,and the color,size,morphology,and structure of the main organs such as heart,liver,pancreas,lung,kidney,brain,stomach,testis,and uterus were not obviously abnormal.The study indicates that Trollius chinensis has low toxicity and high feeding safety.关键词
金莲花/遗传毒性试验/急性毒性试验/亚慢性毒性试验/安全性评价Key words
Trollius chinensis/genotoxicity test/acute toxicity test/subchronic toxicity test/safety evaluation分类
农业科技引用本文复制引用
崔莹,马德志,于侃超,李慧,张可勇,刘吉成..金莲花饲用安全性评价[J].饲料研究,2024,47(4):92-98,7.基金项目
黑龙江省应用技术研究与开发计划项目(项目编号:GA19C009-03) （项目编号:GA19C009-03）
