摘要
Abstract
Objective:To investigate the correlation between thyroid function during pregnancy and premature delivery,and to provide a basis for monitoring thyroid function during pregnancy and preventing adverse neonatal outcomes.Methods:1 248 cases of pregnant women and their newborns who gave birth in Jieyang People's Hospital from January 2021 to June 2023 were selected for the study.Pregnant women age ranged from 18 to 46(27.8±4.1)years old;newborns,675 males and 573 females,with gestational age at birth of 181-295(271.9±13.1)d.Clinical data such as maternal age,pregnancy and childbirth histories,complications during pregnancy,indicators of thyroid function(including thyroid stimulating hormone and free thyroxine),and newborns' birth gestational age and body weight were collected.A multivariate logistic regression model was employed to analyze the relationship between abnormal thyroid function during pregnancy and the risk of premature delivery.Results:The incidence of premature delivery was 6.97%(87/1 248).The results of logistic regression analysis showed that abnormal maternal thyroid stimulating hormone levels(OR=1.981,95%CI:1.009-3.926),abnormal free thyroxine levels(OR=2.823,95%CI:1.442-5.525),low protein(OR=4.651,95%CI:2.190-9.878),gestational hypertension(OR=4.441,95%CI:2.314-8.525),gestational diabetes mellitus(OR=1.846,95%CI:1.002-3.541)may be the correlates of premature delivery(all P<0.05).The differences in thyroid stimulating hormone and free thyroxine levels and their abnormality rates between different trimesters were statistically significant(all P<0.05).Conclusion:Abnormal thyroid function during pregnancy may be correlated with an increased risk of neonatal premature delivery,and monitoring of thyroid stimulating hormone in the second trimester and free thyroxine levels in the third trimester may be helpful in preventing premature delivery.关键词
妊娠期/促甲状腺激素/游离甲状腺素/早产Key words
pregnancy/thyroid stimulating hormone/free thyroxine/premature delivery分类
医药卫生
