生物技术通报2024，Vol.40Issue(3)：75-88,14.DOI:10.13560/j.cnki.biotech.bull.1985.2023-0867
贝莱斯芽孢杆菌生防次级代谢产物研究进展
Research Progress in the Biocontrol Secondary Metabolites of Bacillus velezensis
摘要
Abstract
Bacillus velezensis is an important representative of biocontrol strains in the genus Bacillus.It is widely used as the core strain of biological pesticide in the biocontrol of plant diseases.B.velezensis has endophytic properties in plants,and its biocontrol mechanism mainly includes three aspects.Firstly,it can produce the secondary metabolites against pathogens.Secondly,it can improve host plant microbial community to promote host nutrition and growth.The last,it can stimulate the plant to produce a defense response and develop systemic resistance.Among them,the production of secondary metabolites is the most important mechanism of biocontrol.B.velezensis contains multiple biosynthesis gene clusters encoding secondary metabolites,including gene clusters encoding polyketide synthase(PKS)and non-ribosomal peptide synthase(NRPS),as well as gene clusters for ribosomal pathway synthesis of secondary metabolites.B.velezensis can produce plantazolicin,amylocyclicin,and mersacidin through the ribosomal pathway,and produce lipopeptides,polyketides,bacilysin,and bacillibactin through non-ribosomal pathways.These bioactive secondary metabolites have become repositories of natural new drugs and candidate antibiotics,which is of great significance for analyzing the mechanism of biocontrol action.This paper reviews the naming and alteration,the types of secondary metabolites,synthesis and regulation genes,and target pathogens of B.velezensis.It aims to provide a scientific basis for new theories and applications of strain improvement and plant disease biological control.关键词
贝莱斯芽孢杆菌/生物防治/生防作用机制/次级代谢产物/次级代谢产物基因簇Key words
Bacillus velezensis/biological control/biological control mechanism/secondary metabolites/secondary metabolite gene cluster引用本文复制引用
许沛冬,易剑锋,陈迪,潘磊,谢丙炎,赵文军..贝莱斯芽孢杆菌生防次级代谢产物研究进展[J].生物技术通报,2024,40(3):75-88,14.基金项目
海南省"南海新星"科技创新人才平台项目(NHXXRCXM202358),三亚崖州湾科技城"崖州湾"菁英人才科技专项项目(SCKJ-JYRC-2023-44),三亚市科技创新专项项目(2022KJCX99) （NHXXRCXM202358）
