生命科学仪器2023，Vol.21Issue(6)：22-29,8.DOI:10.11967/2023211204
融合纳米囊泡在癌症治疗中的研究进展
Research Advance of Hybrid Membrane Nanovesicles in Cancer Therapy
摘要
Abstract
Extracellular vesicles(Extracellular vesicles,EVs)with its natural biological characteristics and ac-quired multi-functional advantages,gradually involved in the body's regulation of the physiological and pathologi-cal process,becomes a powerful tool for disease prevention,treatment,and evaluation.Cancer is one of the major diseases that endanger human health at present.Its clinical treatment mainly relies on radiotherapy and chemother-apy,surgical resection and emerging immunotherapy.However,the above treatment methods still have shortcom-ings such as strong drug side effects,low bioavailability,high treatment cost,and easy recurrence,which affect the progress of cancer treatment.Therefore,the emergence of EVs for cancer treatment provides more secure and efficient means.But the low yield,weak self-targeting ability and low drug loading ability of naturally occurring single EVs have limited the development of clinical translation of disease treatment.So,the establishment of multi-functional hybrid membrane nanovesicles with strong universality and good flexibility is the key to expand the prac-tical utility of EVs.This review systematically summarizes the preparation methods,classification characteristics,application and challenges of HMNVs in cancer treatment,and provides theoretical guidance for the development of promising precision medicine nanoplatforms.关键词
细胞外囊泡/外泌体/融合纳米囊泡/膜融合/癌症治疗Key words
extracellular vesicle/exosome/fusion nanovesicles/membrane fusion/cancer treatment分类
医药卫生引用本文复制引用
孙梦,樊玥芸,杨佳妮,胡敏,张金凤..融合纳米囊泡在癌症治疗中的研究进展[J].生命科学仪器,2023,21(6):22-29,8.基金项目
国家自然科学基金资助项目(项目编号:32001010),北京理工大学创新人才科技资助专项计划(项目编号:2022CX01029),广东省基础与应用基础研究基金-面上项目(项目编号:2022A1515011865),广东省医学科研基金-面上项目(项目编号:B2022064) （项目编号:32001010）
