生命科学仪器2023，Vol.21Issue(6)：35-42,8.DOI:10.11967/2023211206
中性粒细胞"异质性"在缺血性卒中的病理生理作用
PathophysiologicalRoles of Neutrophil"Heterogeneity"in Ischemic Stroke
摘要
Abstract
Following ischemic stroke,neutrophils will respond immediately and participate in pathological process such as the blood-brain barrier damage,cerebral edema and hemorrhage transformation.Thus anti-neutrophils treatment such as inhibiting the activation,adhesion and the release of proteases and cytokine used to be the thera-peutic target and research hotspot in ischemic stroke.Although basic research is promising,it is difficult to trans-late into clinical application.One important reason is the"heterogeneity"of neutrophils,e.g.their function and underlying mechanisms are dynamic.In-depth study and fully understanding the neutrophils"heterogeneity"can not only make us further understand the pathophysiological roles that neutrophils play following ischemic stroke,but also help solve the problems in the transition from basic research to clinical practice,which would pave a way for treatment of ischemic stroke.Current studies have shown that neutrophils heterogeneity exists in various as-pects including developmental stage,function,the expression of phenotypic protein,patients-age relevant and dis-tribution during the progression of ischemic stroke.This review intends to elaborate on the above aspects.关键词
缺血性卒中/中性粒细胞/异质性Key words
Ischemic stroke/Neutrophils/Heterogeneity分类
医药卫生引用本文复制引用
韩子萍,唐雨琦,李灵芝,罗玉敏..中性粒细胞"异质性"在缺血性卒中的病理生理作用[J].生命科学仪器,2023,21(6):35-42,8.基金项目
国家自然科学基金面上项目(81971222 （）
82171298) （）
