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Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity

Shuai Zhang Tingting Wang Ye Feng Fei Li Aijuan Qu Xiuchen Guan Hui Wang Dan Xu

药物分析学报（英文）2023，Vol.13Issue(12)：1510-1525,16.

药物分析学报（英文）2023，Vol.13Issue(12)：1510-1525,16.DOI:10.1016/j.jpha.2023.07.013

Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity

Shuai Zhang ¹Tingting Wang ¹Ye Feng ²Fei Li ³Aijuan Qu ⁴Xiuchen Guan ⁵Hui Wang ⁶Dan Xu¹

作者信息

1. Department of Obstetric,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University,Wuhan,430071,China||Hubei Provincial Key Laboratory of Developmentally Originated Disease,Wuhan University,Wuhan,430071,China
2. Department of Endocrinology and Metabolic Disease,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310058,China
3. Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu,610041,China
4. Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing,100069,China||Key Laboratory of Remodeling-related Cardiovascular Diseases,Ministry of Education,Beijing,100069,China
5. Department of Orthodontics,School of Stomatology,Capital Medical University,Beijing,100069,China
6. Department of Pharmacology,School of Basic Medical Sciences,Wuhan University,Wuhan,430071,China||Hubei Provincial Key Laboratory of Developmentally Originated Disease,Wuhan University,Wuhan,430071,China
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摘要

关键词

Pregnenolone 16α-carbonitrile/Pregnane X receptor/Hippocampus/Glucocorticoid receptor/Phenytoin sodium/Neurotoxicity

Key words

Pregnenolone 16α-carbonitrile/Pregnane X receptor/Hippocampus/Glucocorticoid receptor/Phenytoin sodium/Neurotoxicity

引用本文复制引用

Shuai Zhang,Tingting Wang,Ye Feng,Fei Li,Aijuan Qu,Xiuchen Guan,Hui Wang,Dan Xu..Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity[J].药物分析学报（英文）,2023,13(12):1510-1525,16.

基金项目

This work was supported in part by grants from the National Natural Science Foundation of China(Grant Nos.:81973405,82122071,and 82030111)to Dan Xu and Hui Wang,the National Key R&D Program of China(Grant No.:2020YFA0803900)to Hui Wang,and the Hubei Provincial Natural Science Foundation Outstanding Youth Found,China(Grant No.:2022CFA083). （Grant Nos.:81973405,82122071,and 82030111）

药物分析学报（英文）

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ISSN：2095-1779

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