锰掺杂纳米羟基磷灰石的体外抗菌-促成骨性能研究OA北大核心CSTPCD

Hydroxyapatite(HAP),as a common bone repair material,still faces the risk of bacterial infection in the treatment of infectious bone defects,whose limited osteogenic properties also hinders its further application.This study used a coprecipitation method to prepare the manganese doped hydroxyapatite nanorod(MnHAP),which exhibited excellent cell biocompatibility,high antibacterial efficiency and osteogenic properties.Antibacterial experiments showed that the inhibition rates of MnHAP10(n(Mn)/n(Ca+Mn)=10%))against Escherichia coli and Staphylococcus aureus can reach 77.85%and 75.92%,respectively.Moreover,the antibacterial efficiency of MnHAP10 against Escherichia coli can be further enhanced(97.63%)under 808 nm near-infrared light irradiation.Cell proliferation and related osteogenic gene experiments display that MnHAP is beneficial for the proliferation and differentiation of osteoblasts,which improves protein adsorption capacity,stimulates osteogenic activity,and promotes the expression of related osteogenic genes,demonstrating its good biocompatibility.Therefore,MnHAP nanorods are expected to provide a new approach in the treatment of infectious bone defects.