首页|期刊导航|药物分析学报（英文）|Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

Yang Yi Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Wenzhe Li Hang Yang Min Ye Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan

药物分析学报（英文）2024，Vol.14Issue(1)：115-127,13.

药物分析学报（英文）2024，Vol.14Issue(1)：115-127,13.DOI:10.1016/j.jpha.2023.05.011

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

Yang Yi ¹Yuxi Huang ¹Jing Wang ¹Xiaomeng Shi ¹Junhua Li ²Hongping Wei ²Kuanhui Xiang ³Linjie Li ⁴Rong Zhang ⁴Xin Zhao ⁴Xue Qiao ¹Wenzhe Li ¹Hang Yang ⁵Min Ye ⁶Kefang Liu ⁷Heng Xue ²Rong Yu ¹Meng Zhang ¹Yang-Oujie Bao ¹Xinyuan Lai ³Jingjing Fan¹

作者信息

1. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China
2. CAS Key Laboratory of Special Pathogens and Biosafety,Center for Biosafety Mega-Science,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China||University of Chinese Academy of Sciences,Beijing,100049,China
3. Department of Microbiology and Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,Peking University,Beijing,100191,China
4. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China||University of Chinese Academy of Sciences,Beijing,100049,China
5. CAS Key Laboratory of Special Pathogens and Biosafety,Center for Biosafety Mega-Science,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China||University of Chinese Academy of Sciences,Beijing,100049,China||Hubei Jiangxia Laboratory,Wuhan,430000,China
6. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China||Yunnan Baiyao International Medical Research Center,Peking University,Beijing,100191,China
7. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,100101,China||University of Chinese Academy of Sciences,Beijing,100049,China||Shenzhen Children's Hospital,Shenzhen,Guangdong,518036,China
折叠

摘要

关键词

COVID-19/Inflammation/Licorice-saponin A3/Receptor-binding domain(RBD)/SARS-CoV-2

Key words

COVID-19/Inflammation/Licorice-saponin A3/Receptor-binding domain(RBD)/SARS-CoV-2

引用本文复制引用

Yang Yi,Yuxi Huang,Jing Wang,Xiaomeng Shi,Junhua Li,Hongping Wei,Kuanhui Xiang,Linjie Li,Rong Zhang,Xin Zhao,Xue Qiao,Wenzhe Li,Hang Yang,Min Ye,Kefang Liu,Heng Xue,Rong Yu,Meng Zhang,Yang-Oujie Bao,Xinyuan Lai,Jingjing Fan..Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation[J].药物分析学报（英文）,2024,14(1):115-127,13.

基金项目

This work was supported by National Natural Science Founda-tion of China(Grant Nos.:81891010/81891011,81725023,82003614,82173950,31770192,32070187,32161133003 and 82003681)and China Postdoctoral Science Foundation(Grant No:2022T150029).We thank Professor George Fu Gao from CAS Institute of Microbiology for helpful and constructive suggestions.We also thank Tao Du,Lun Wang,Jin Xiong,and the entire running team from Zhengdian Biosafety Level 3 Laboratory of Wuhan Institute of Virology for technical support.We thank the Wroclaw Center for Networking and Super Computing for providing generous computer time,and Jingjie PTM BioLab Co.,Ltd.(Hang-zhou,China)for proteomics mass spectrometry analysis. （Grant Nos.:81891010/81891011,81725023,82003614,82173950,31770192,32070187,32161133003 and 82003681）

药物分析学报（英文）

ISSN：2095-1779

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