中国骨伤2024，Vol.37Issue(3)：300-305,6.DOI:10.12200/j.issn.1003-0034.20220937
自体骨移植与骨替代物手术治疗胫骨平台骨折的Meta分析
Meta-analysis of autologous bone grafts and bone substitute for the treatment of tibial plateau fractures
摘要
Abstract
Objective To explore clinical efficacy of autologous bone grafts and bone substitute for the treatment of tibial plateau fractures by Meta analysis.Methods Controlled clinical studies on autogenous bone transplantation and bone substitutes in treating tibial plateau fractures published on PubMed,Web of Science,CNKI,Wanfang and other databases from January 2005 to August 2022 were searched by computer.Literature screening and data extraction were performed according to random-ized controlled trial(RCT),and the quality of RCT were evaluated by using intervention meta-analysis criteria in Cochrane man-ual.Meta-analysis of joint depression,secondary collapse rate of articular surface,blood loss,operative time and infection rate between two methods were performed by Rev Man 5.3 software.Results Seven RCT studies(424 patients)were included,296 patients in bone replacement group and 128 patients in autograft group.Operative time[MD=-16.79,95％CI(-25.72,-7.85),P=0.000 2]and blood loss[MD=-70.49,95％CI(-79.34,-61.65),P＜0.000 01]between two groups had statistically differ-ences,while joint depression[MD=-0.17,95％CI(-0.91,0.58),P=0.66],secondary collapse rate of joint surface[RR=-0.74,95％CI(0.35,1.57),P=0.43],infection rate[RR=1.21,95％CI(0.31,4.70),P=0.78]between two groups had no differences.Conclusion The effects of bone substitute and autograft for the treatment of tibial plateau fracture have similar effects in terms of joint depression,secondary articular surface collapse rate and infection rate.However,compared with autologous bone trans-plantation,bone replacement could reduce blood loss and shorten operation time.关键词
胫骨平台骨折/自体骨移植/骨替代物/Meta分析Key words
Tibial plateau fracture/Autologous bone graft/Bone substitute/Meta-analysis分类
医药卫生引用本文复制引用
郭华,黄凌岸,李皓乾,郭丽,李鹏翠,卫小春..自体骨移植与骨替代物手术治疗胫骨平台骨折的Meta分析[J].中国骨伤,2024,37(3):300-305,6.基金项目
国家自然科学基金区域联合重点资助项目(编号:U21A20353) （编号:U21A20353）
山西省基础研究计划自然科学研究面上项目(编号:20210302123285)Supported by National Natural Science Foundation of China Regional Joint Key Funding Project(No.U21A20353) （编号:20210302123285）
