协和医学杂志2024，Vol.15Issue(2)：351-358,8.DOI:10.12290/xhyxzz.2023-0553
日常咖啡摄入与疼痛的关系:基于NHANES数据库的大样本横断面研究
Association Between Coffee Consumption and Pain:A Cross-sectional Study Based on American National Health and Nutrition Examination Survey
摘要
Abstract
Objective To elucidate whether coffee consumption and caffeine intake was associated with various subtypes of pain based on extensive data from publicly accessible databases.Methods The information was extracted from three cycles of the American National Health and Nutrition Examination Survey(1999-2000,2001-2002,2003-2004),encompassing data on coffee consumption,pain information,and 11 cova-riates(including age,gender,race,etc.).Multinomial logistic regression in three models were utilized for analysis.Results A total of 13 428 participants were included in this study,with a mean age of(49.79±19.06)years and a male-to-female ratio of 0.9 ∶ 1.Daily coffee intake:non-drinker 7794(58.0%),＞0-2 cups 2077(15.5%),＞2 cups 3557(26.5%);daily caffeine intake:without intake 7794(58.0%),＞0-200 mg 3152(23.5%),＞200 mg 2482(18.5%);pain situation:no pain or pain duration＜24 h 10202(76.0%),acute pain 910(6.8%),subacute pain 369(2.7%),chronic pain 1947(14.5%).After weighting,13428 participants were expected to represent 190 million(190709157)U.S.citizens aged≥20 years,and the overall prevalence of acute,subacute,and chronic pain in the U.S.population during that period was estimated to be 8%,3%,and 16%,respectively.Without adjusting for covariates,individuals who consumed more than 2 cups of coffee or 200 mg of caffeine per day exhibited an elevated risk of chronic pain compared to non-coffee/caffeine drinkers,with an odds ratio of 1.354(95%CI:1.187-1.544)and 1.372(95%CI:1.185-1.587),respectively.After adjusting for partial covariates including age,sex,and race,individuals who consumed more than 2 cups of coffee or more than 200 mg of caffeine per day still demon-strated an increased risk of chronic pain with an odds ratio of 1.243(95%CI:1.083-1.427)and 1.249(95%CI:1.072-1.456),respectively.However,after all covariates were adjusted,there was no significant association between coffee/caffeine consumption and chronic pain.Furthermore,the number of cups of coffee consumed or caffeine intake showed no significant correlation with acute and subacute pain.Conclusions Compared with nondrinkers,heavy daily coffee drinkers may be more likely to have chronic pain,but it is af-fected by multiple factors.Basic research and prospective clinical studies are needed to further determine the causality in this association.关键词
急性疼痛/亚急性疼痛/慢性疼痛/咖啡/咖啡因/横断面研究Key words
acute pain/subacute pain/chronic pain/coffee/caffeine/cross-sectional study分类
医药卫生引用本文复制引用
闻蓓,朱贺,许力,黄宇光..日常咖啡摄入与疼痛的关系:基于NHANES数据库的大样本横断面研究[J].协和医学杂志,2024,15(2):351-358,8.基金项目
国家自然科学基金(82271262) National Natural Science Foundation of China(82271262) （82271262）
