协和医学杂志2024，Vol.15Issue(2)：382-386,5.DOI:10.12290/xhyxzz.2023-0452
阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中:机制与研究进展
Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke:Mechanism and Research Progress
摘要
Abstract
Ischemic stroke,a cerebrovascular disease with high incidence,high mortality,high disability rate and high recurrence rate,is an important cause of death and disability of middle-aged and elderly people in China,and imposes a huge burden to society and families.Therefore,it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them.Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke.However,the exact pathological mechanism of their association has not been clarified.With the development of next-generation sequencing technology,more and more studies have focused on intestinal microbiota.They have found that obstructive sleep apnea can cause intestinal microbiota changes,and intestinal microbiota may be closely related to ischemic stroke.Therefore,this paper attempts to investigate the relationship between intestinal flora and ischemic stroke,so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea.关键词
阻塞性睡眠呼吸暂停/肠道菌群/缺血性脑卒中/危险因素/短链脂肪酸/三甲胺-N-氧化物Key words
obstructive sleep apnea/intestinal flora/ischemic stroke/risk factors/short-chain fatty acids/trimethyl-amine-N-oxide分类
医药卫生引用本文复制引用
刘苗苗,岳红梅,李雅亭,许金回,武兴东,朱浩斌..阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中:机制与研究进展[J].协和医学杂志,2024,15(2):382-386,5.基金项目
甘肃省科技计划(22ZD1FA00A) Science and Technology Project of Gansu Province(22ZD1FA00A) （22ZD1FA00A）
