中国临床药理学杂志2024，Vol.40Issue(6)：918-922,5.DOI:10.13699/j.cnki.1001-6821.2024.06.028
中医药调控TGF-β1/Smads信号通路干预肝纤维化的研究现状
Research status on the mechanism of traditional Chinese medicine regulating TGF-β1/Smads signaling pathway to intervene liver fibrosis
摘要
Abstract
Hepatic fibrosis(HF)is a pathophysiological outcome of chronic liver injury and is characterized by excessive accumulation of extracellular matrix protein.A number of studies have confirmed that the signaling pathways formed by transforming growth factor-β1(TGF-β1)and its downstream Smad family play an important role in the occurrence and development of HF,and the traditional Chinese medicine(TCM)research targeting this pathway is currently a hot spot in the reversal of HF.Therefore,taking TGF-β1/Smads signaling pathway as the entry point,this paper reviewed the mechanism of action of TCM compound formula and single drug extract in intervening TGF-β1/Smad pathway and related factors upstream and downstream of the pathway to reverse HF in recent years,revealed the targeted therapeutic effect of TCM,and provided new strategies for clarifying the mechanism of TCM.关键词
中医药/肝纤维化/转化生长因子-β1/Smads信号通路Key words
traditional Chinese medicine/hepatic fibrosis/transforming growth factor-β1/Smads signaling pathway分类
医药卫生引用本文复制引用
陶永彪,杨世睿,汪龙德,吴亚娜,张志明,李赋..中医药调控TGF-β1/Smads信号通路干预肝纤维化的研究现状[J].中国临床药理学杂志,2024,40(6):918-922,5.基金项目
甘肃省中西医结合肿瘤临床医学研究中心课题基金资助项目(18JR2FA001) （18JR2FA001）
甘肃省名中医传承工作室建设项目(国中药规财函[2021]242) （国中药规财函[2021]242）
