中国临床药理学杂志2024，Vol.40Issue(6)：923-927,5.DOI:10.13699/j.cnki.1001-6821.2024.06.029
基于NLRP3炎症小体探讨中药抗炎作用的研究现状
Research status of anti-inflammatory effect of traditional Chinese medicine based on NLRP3 inflammatory body
摘要
Abstract
Inflammasome is a kind of intracellular polyprotein complex,which is an important component of the complex system of local inflammatory microenvironment after human tissue damage.When the inflammasome is activated,it induces the activation of cysteine aspartate proteinase 1(caspase-1),mediates the maturation and secretion of proinflammatory cytokines,such as interleukin(IL)-1 β and IL-18,and induces cell death,which plays an important role in regulating the host immune response to pathogen infection and tissue repair of cell damage.Nod-like receptor protein 3(NLRP3)inflammatory body,which is composed of NLRP3,pro-cysteine aspartic acid specific protease-1(pro-caspase-1)and apoptosis-related spot-like protein(ASC),is the most deeply and widely studied type of inflammatory body,which plays an important role in the regulation of inflammation.When NLRP3 inflammatory bodies are activated,inflammatory mediators are produced and released,which participate in the occurrence and development of a variety of inflammatory diseases.Some studies have shown that traditional Chinese medicine can improve the pathological state of a variety of diseases by inhibiting NLRP3 inflammatory bodies,and play a role in the prevention and treatment of a variety of inflammatory diseases,including cardiovascular diseases,joint inflammation,diabetes and so on.This paper systematically combs the mechanism of NLRP3 inflammatory bodies,and summarizes the latest research reports on the effects of traditional Chinese medicine compound prescription,traditional Chinese medicine monomers and traditional Chinese medicine extracts on NLRP3 inflammatory bodies in the treatment of inflammatory diseases,in order to provide new ideas for the further study of the pathogenesis and drug treatment of many inflammatory diseases.关键词
中药/NOD样受体蛋白3炎症小体/抗炎/机制Key words
traditional Chinese medicine/Nod-like receptor protein 3 inflammasome/anti-inflammation/mechanism分类
医药卫生引用本文复制引用
徐富梅,曾俊媛,赵磊,张启立,夏鹏飞,贾寅强,王洁,方鹏霞,续艳丽..基于NLRP3炎症小体探讨中药抗炎作用的研究现状[J].中国临床药理学杂志,2024,40(6):923-927,5.基金项目
国家自然科学基金资助项目(82160457,81660577) （82160457,81660577）
甘肃省教育厅"双一流"科研重点基金资助项目(GSSYLXM-05) （GSSYLXM-05）
甘肃省科技计划基金资助项目(21JR7RA564) （21JR7RA564）
甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金资助项目(ddyc-2022-03) （ddyc-2022-03）
甘肃省药品科研基金资助项目(2023GSMPA078) （2023GSMPA078）
