中国医学装备2024，Vol.21Issue(3)：48-52,5.DOI:10.3969/j.issn.1672-8270.2024.03.010
冠状动脉CT血管造影及血清指标对冠心病冠状动脉狭窄程度的评价
Evaluation of 256 slice spiral CTA of coronary and serum indicators on the severity of coronary artery stenosis of patients with coronary heart disease
摘要
Abstract
Objective:To explore the evaluation of 256 slice spiral computed tomography angiography(CTA)of coronary,serum lipoprotein associated phospholipase A2(Lp-PLA2)and angiopoietin like protein 3(ANGPTL3)on the severity of coronary artery stenosis of patients with coronary heart disease.Methods:A total of 102 patients with coronary heart disease who were diagnosed and treated at Hebei Chest Hospital from July 2022 to March 2023 were selected as the study subjects.According to the Gensini score about the severity of coronary artery stenosis,they were divided into mild stenosis group(0 score≤Gensini score≤20 scores),moderate stenosis group(20 scores<Gensini score≤60 scores)and severe stenosis group(Gensini score>60 scores),with 34 cases in each group.The minimum lumen diameter(MLD),percentage of area of stenosis(%AS),percentage of diameter of stenosis(%DS),minimum lumen area(MLA),Lp-PLA2 and ANGPTL3 among three groups were compared.The diagnostic efficiency of the severity of coronary artery stenosis was predicted according to receiver operating characteristic(ROC)curve.Results:The MLA and MLD values in severe stenosis group were significantly lower than those in moderate and mild stenosis groups,while%AS and%DS were significantly higher than those in moderate and mild stenosis groups(t=6.905,4.083,5.871,6.976,3.387,2.198,2.668,3.505,P<0.05),respectively.The Lp-PLA2 and ANGPTL3 values in severe stenosis group were significantly higher than those in moderate and mild stenosis groups(t=4.164,8.220,2.575,3.050,P<0.05),respectively.ROC curve analysis showed that the area under curve(AUC)values of MLA,MLD,%AS,%DS,CCTA comprehensive parameter,LpPLA2 and ANGPTL3 were respectively were 0.838,0.690,0.742,0.801,0.904,0.808 and 0.807 in predicting the severity of coronary artery stenosis.The sensitivities of them were respectively 91.20%,91.20%,64.70%,94.10%,97.10%,70.60%and 88.20%.The specificities of them were respectively 76.50%,57.40%,75.00%,50.00%,70.60%,97.10%and 70.60%.The AUC value of CCTA comprehensive parameter was respectively higher than that of LpPLA2 and ANGPTL3,but the difference was not statistically significant(P>0.05).Conclusion:256 slice spiral CCTA,serum Lp-PLA2 and ANGPTL3 have a certain efficiency in assessing the severity of coronary artery stenosis of coronary heart disease,and 256 slice spiral CCTA has higher predictive efficiency.关键词
螺旋CT/冠状动脉CT血管造影(CCTA)/脂蛋白相关磷脂酶A2(A2Lp-PLA2)/血管生成素样蛋白3(ANGPTL3)/冠心病冠状动脉狭窄Key words
Spiral computed tomography/Coronary computed tomography angiography(CCTA)/Lipoprotein associated phospholipase A2(Lp-PLA2)/Angiopoietin like protein 3(ANGPTL3)/Coronary artery stenosis of coronary heart disease分类
医药卫生引用本文复制引用
赵宇明,赵树媛,侯鹏,王爽,纪俊雨..冠状动脉CT血管造影及血清指标对冠心病冠状动脉狭窄程度的评价[J].中国医学装备,2024,21(3):48-52,5.基金项目
河北省卫生健康委员会科研项目(20231208) Research project number of Hebei Provincial Health Commission(20231208) （20231208）
