冠状动脉CT血管造影及血清指标对冠心病冠状动脉狭窄程度的评价OACSTPCD
Evaluation of 256 slice spiral CTA of coronary and serum indicators on the severity of coronary artery stenosis of patients with coronary heart disease
目的:探讨冠状动脉CT血管造影(CCTA)及血清脂蛋白相关磷脂酶A2(Lp-PLA2)、血管生成素样蛋白3(ANGPTL3)对冠心病冠状动脉狭窄程度的评价.方法:选取2022年7月至2023年3月河北省胸科医院诊治的102例冠心病患者,按照冠状动脉狭窄程度积分(Gensini积分)情况将其分为轻度组(0分≤Gensini积分≤20分)、中度组(20分＜Gensini积分≤60分)及重度组(Gensini积分＞60分),每组34例.对比3组患者冠状动脉最小管腔直径(MLD)、狭窄面积百分比(%AS)、狭窄直径百分比(%DS)、最小管腔面积(MLA)、Lp-PLA2及ANGPTL3,根据受试者工作特征(ROC)曲线,预测冠状动脉狭窄程度的诊断效能.结果:重度组MLA、MLD低于中度组和轻度组,而%AS、%DS高于中度组和轻度组,差异有统计学意义(t=6.905、4.083、5.871、6.976、3.387、2.198、2.668、3.505,P＜0.05).重度组Lp-PLA2、ANGPTL3高于中度组和轻度组,差异有统计学意义(t=4.164、8.220、2.575、3.050,P＜0.05).ROC曲线分析显示,MLA、MLD、%AS、%DS、CCTA综合参数、LpPLA2以及ANGPTL3预测冠状动脉狭窄程度的ROC曲线下面积(AUC)值分别为0.838、0.690、0.742、0.801、0.904、0.808和0.807.灵敏度分别为91.20%、91.20%、64.70%、94.10%、97.10%、70.60%和88.20%;特异度分别为76.50%、57.40%、75.00%、50.00%、70.60%、97.10%和70.60%.CCTA综合参数的AUC分别高于LpPLA2和ANGPTL3,但差异无统计学意义(P＞0.05).结论:CCTA及血清Lp-PLA2、ANGPTL3评估冠心病冠状动脉狭窄程度均具有一定效能,且CCTA的预测效能更高.
Objective:To explore the evaluation of 256 slice spiral computed tomography angiography(CTA)of coronary,serum lipoprotein associated phospholipase A2(Lp-PLA2)and angiopoietin like protein 3(ANGPTL3)on the severity of coronary artery stenosis of patients with coronary heart disease.Methods:A total of 102 patients with coronary heart disease who were diagnosed and treated at Hebei Chest Hospital from July 2022 to March 2023 were selected as the study subjects.According to the Gensini score about the severity of coronary artery stenosis,they were divided into mild stenosis group(0 score≤Gensini score≤20 scores),moderate stenosis group(20 scores<Gensini score≤60 scores)and severe stenosis group(Gensini score>60 scores),with 34 cases in each group.The minimum lumen diameter(MLD),percentage of area of stenosis(%AS),percentage of diameter of stenosis(%DS),minimum lumen area(MLA),Lp-PLA2 and ANGPTL3 among three groups were compared.The diagnostic efficiency of the severity of coronary artery stenosis was predicted according to receiver operating characteristic(ROC)curve.Results:The MLA and MLD values in severe stenosis group were significantly lower than those in moderate and mild stenosis groups,while%AS and%DS were significantly higher than those in moderate and mild stenosis groups(t=6.905,4.083,5.871,6.976,3.387,2.198,2.668,3.505,P<0.05),respectively.The Lp-PLA2 and ANGPTL3 values in severe stenosis group were significantly higher than those in moderate and mild stenosis groups(t=4.164,8.220,2.575,3.050,P<0.05),respectively.ROC curve analysis showed that the area under curve(AUC)values of MLA,MLD,%AS,%DS,CCTA comprehensive parameter,LpPLA2 and ANGPTL3 were respectively were 0.838,0.690,0.742,0.801,0.904,0.808 and 0.807 in predicting the severity of coronary artery stenosis.The sensitivities of them were respectively 91.20%,91.20%,64.70%,94.10%,97.10%,70.60%and 88.20%.The specificities of them were respectively 76.50%,57.40%,75.00%,50.00%,70.60%,97.10%and 70.60%.The AUC value of CCTA comprehensive parameter was respectively higher than that of LpPLA2 and ANGPTL3,but the difference was not statistically significant(P>0.05).Conclusion:256 slice spiral CCTA,serum Lp-PLA2 and ANGPTL3 have a certain efficiency in assessing the severity of coronary artery stenosis of coronary heart disease,and 256 slice spiral CCTA has higher predictive efficiency.
赵宇明;赵树媛;侯鹏;王爽;纪俊雨
河北省胸科医院放射科 石家庄 050000河北省胸科医院功能科 石家庄 050000
临床医学
螺旋CT冠状动脉CT血管造影(CCTA)脂蛋白相关磷脂酶A2(A2Lp-PLA2)血管生成素样蛋白3(ANGPTL3)冠心病冠状动脉狭窄
Spiral computed tomographyCoronary computed tomography angiography(CCTA)Lipoprotein associated phospholipase A2(Lp-PLA2)Angiopoietin like protein 3(ANGPTL3)Coronary artery stenosis of coronary heart disease
《中国医学装备》 2024 (003)
48-52 / 5
河北省卫生健康委员会科研项目(20231208) Research project number of Hebei Provincial Health Commission(20231208)
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