安徽医科大学学报2024，Vol.59Issue(2)：289-292,4.DOI:10.19405/j.cnki.issn1000-1492.2024.02.017
桥本甲状腺炎UGRP1与Fas介导的凋亡通路的相关性研究
Correlation between UGRP1 and apoptosis pathway mediated by Fas in hashimoto thyroiditis
摘要
Abstract
Objective To investigate the correlation between uterine globulin associated protein 1(UGRP1)and Fas mediated apoptosis pathway in hashimoto thyroiditis(HT).Methods The expression of UGRP1 in thyroid cells of normal people and HT patients was detected by immunohistochemistry(IHC).FRTL-5 cells were transfect-ed by plasmids in vitro,and control group,UGRP1 group,Fas group were established respectively.Real-time fluo-rescent quantitative reverse transcription PCR(RT-qPCR)was used to detect the expression of Fas and UGRP1 mRNA in each group.Results UGRP1 expression was positive in thyroid cells of HT patients and negative in that of normal people.There were no significant differences between control group and UGRP1 group in Fas gene ex-pression(1.085 0±0.124 9 vs 1.021 0±0.113 9).Compared with the control group,the expression of UGRP1 gene increased significantly in Fas group(P＜0.000 1,5.807 0±0.323 2 vs 0.752 7±0.076 0).Conclusion The high expression of UGRP1 in HT may be related to apoptosis pathway mediated by Fas.关键词
子宫球蛋白相关蛋白1/Fas/FasL通路/桥本甲状腺炎Key words
uterine globulin associated protein 1/Fas/FasL pathway/hashimoto thyroiditis分类
医药卫生引用本文复制引用
马珊珊,吴月,朱莉,陆晨阳,左春林..桥本甲状腺炎UGRP1与Fas介导的凋亡通路的相关性研究[J].安徽医科大学学报,2024,59(2):289-292,4.基金项目
国家自然科学基金(编号:81270864) （编号:81270864）
