桂林理工大学学报2024，Vol.44Issue(1)：155-161,7.DOI:10.3969/j.issn.1674-9057.2024.01.022
含松香的聚氨酯载药微球的制备及性能
Preparation and properties of rosin-containing polyurethane drug-loaded microspheres
摘要
Abstract
Rosin-based polyurethane microspheres(5-Fu/RPUMs)are prepared by suspension polymerization u-sing 5-fluorouracil(5-Fu)as the model drug rosin-based polyurethane(RPU)synthesized by prepolymerization,and extension and neutralization method as the carrier single factor experiment is used to optimize drug-loaded conditions.Infrared spectrometer X-ray photoelectron spectroscopy,scanning electron microscopy and energy dis-persive spectrometer are used to characterize drug-loaded microspheres.The in-vitro release performance and drug release kinetics model of drug-loaded microspheres are studied.The results show that 5-Fu/RPUMs are success-fully prepared with an average particle size of 35.0 μm and a smooth,rounded surface with holes.The optimal loading conditions are ρ5-Fu =120 mg/mL and n-butanol/toluene as pore-forming agent.Under these conditions,the encapsulation rate of RPU to 5-Fu reaches 63.35%and the drug loading is 7.60%.5-Fu/RPUMs is pH sensi-tive showing different sustainable release at different pH.In PBS buffer solution with pH=6.8,the cumulative re-lease rate after 264 h is 65.80%,showing a long-acting sustainable release effect.关键词
松香/聚氨酯微球/载药/释放Key words
rosin/polyurethane microspheres/drug-loaded/release分类
化学化工引用本文复制引用
严成飞,张发爱,邵金涛,余彩莉..含松香的聚氨酯载药微球的制备及性能[J].桂林理工大学学报,2024,44(1):155-161,7.基金项目
国家自然科学基金项目(51863007) （51863007）
