结核与肺部疾病杂志2024，Vol.5Issue(2)：106-112,7.DOI:10.19983/j.issn.2096-8493.2024027
低剂量CT筛查对人群肺癌死亡率及全因死亡率影响的Meta分析
Meta-analysis of the impact of low-dose CT screening on population lung cancer-specific mortality and all-cause mortality
摘要
Abstract
Objective:To systematically evaluate the effectiveness of low-dose computed tomography screening(LDCT)in reducing lung cancer-specific mortality and all-cause mortality among screened populations.Methods:A comprehensive search was conducted in databases such as PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure(CNKI),and Wanfang Data Knowledge Service Platform for prospective studies on LDCT lung cancer screening,published domestically and internationally from January 2000 to August 2023.Data extraction and quality assessment were performed on studies meeting the inclusion criteria.The primary outcome was lung cancer-specific mortality,while secondary outcomes included all-cause mortality and the number need to be screened(NNBS)to prevent one lung cancer death or death from all causes.Meta-analysis was conducted using R software version 4.3.1.Results:Nine studies with a prospective design were included,covering 123 880 individuals screened,aged 40-75 years.The median follow-up time of the studies ranged from 3.6 to 13.0 years.Meta-analysis results showed that compared to non-LDCT screening groups,LDCT screening reduced lung cancer-specific mortality by 16％(RR=0.84,95％CI:0.78-0.91,P＜0.001).There was no significant difference in the all-cause mortality(RR=0.93,95％CI:0.84-1.03,P=0.151).Subgroup analysis indicated that the specific subcategories of the non-LDCT screening group(control group)were related to the reduction in lung cancer mortality.Meta-regression results showed that the median follow-up time was related to the reduction in all-cause mortality.To prevent one death caused by lung cancer through LDCT screening,139 people were estimated to be screened in the non-imaging prevention/general population;to prevent one death caused by all-cause,81 people were estimated to be screened.Conclusion:LDCT screening significantly reduces lung cancer-specific mortality in the 40-75 age group,underlining its important public health significance for specific age groups and risk populations.关键词
肺肿瘤/体层摄影扫描仪,X线计算机/诊断检查服务/死亡率/Meta分析(主题)Key words
Lung neoplasms/Tomography scanners,X-ray computed/Diagnostic services/Mortality/Meta-analysis as topic分类
医药卫生引用本文复制引用
字晓慧,吴芄,郑苏菲,孙楠,赫捷..低剂量CT筛查对人群肺癌死亡率及全因死亡率影响的Meta分析[J].结核与肺部疾病杂志,2024,5(2):106-112,7.基金项目
国家重点研发专项(2022YFC3603003)National Key Research and Development Program of China(2022YFC3603003) （2022YFC3603003）
