结核与肺部疾病杂志2024，Vol.5Issue(2)：143-147,5.DOI:10.19983/j.issn.2096-8493.2024030
干扰素诱导蛋白3联合降钙素原对老年重症肺结核患者预后的评估价值
Clinical value of IFIT3 and PCT in prognosis evaluation of elderly patients with severe tuberculosis
摘要
Abstract
Objective:To investigate the value of IFIT3(interferon-induced protein with tetratricopeptide repeats 3,IFIT3)and procalcitonin(PCT)in the prognosis of elderly patients with severe pulmonary tuberculosis(PTB).Methods:In this prospective study,82 elderly patients with severe PTB in the ICU of Hebei Chest Hospital from April 2022 to March 2023 were selected as study objects,and divided into survival group(42 cases)and death group(40 cases)according to the outcomes of the patients after they admitted to the ICU for 28 days.Clinical data of these two groups of patients were collected,and serum IFIT3 and PCT contents were determined by enzyme-linked immunosorbent assay(ELISA).The predictive value of IFIT3 and PCT on death was then analyzed by plotting receiver operating characteristic(ROC)curve,while the prognosis at 28 days after admission to ICU was used as the reference standard.Results:The acute physiology and chronic health status assessment system Ⅱ(APACHE Ⅱ)score,serum IFIT3 and PCT level of the elderly patients with severe PTB in the death group were 25.68±8.12,21.00(13.00,48.00)pg/ml and 3.21(0.96,5.78)ng/ml,respectively,higher than those in the survival group(21.17±8.57,11.00(5.75,22.75)pg/ml and 0.41(0.15,1.04)ng/ml).The differences were statistically significant(t=-2.373,P=0.018;Z=-2.920,P=0.003;Z=2.028,P=0.001).The area under ROC curve(AUC)of IFIT3 and PCT were 0.687(95％CI:0.572-0.803)and 0.832(95％CI:0.741-0.922)respectively for predicting death.When the optimal threshold value of IFIT3 was 12.50 pg/ml,the sensitivity and specificity of predicting death were 77.5％and 59.5％.When the optimal threshold of serum PCT was 1.44 ng/ml,the sensitivity and specificity of predicting death were 72.5％and 83.3％.AUC of combing IFIT3 with PCT in predicting death was 0.850(95％CI:0.767-0.933),the sensitivity and specificity were 75.0％and 83.3％,and the positive predictive value and negative predictive value were 81.1％and 75.6％.Conclusion:IFIT3 combined with PCT test has a certain clinical value in the prognosis assessment of elderly patients with severe PTB in ICU.关键词
干扰素诱导剂/重症监护病房/老年人/预测Key words
Interferon inducers/Intensive care units/Aged/Forecasting分类
医药卫生引用本文复制引用
魏云霞,王鑫,龙雪娟,邵丽娇,闫丽静,于娣,李宁..干扰素诱导蛋白3联合降钙素原对老年重症肺结核患者预后的评估价值[J].结核与肺部疾病杂志,2024,5(2):143-147,5.基金项目
河北省医学科学研究重点课题计划(20191014) （20191014）
政府资助临床医学优秀人才培养项目 Hebei Province Medical Science Research Key Project Plan(20191014) （20191014）
The Government Subsidized Training Program for Clinical Medical Excellence （）
