摘要
Abstract
Objective:To evaluate the efficacy of conventional hypoglycemic and anti-tuberculosis therapy combined with thymosin α1 in pulmonary tuberculosis patients complicated with diabetes mellitus.Methods:Relevant literature was searched for in both Chinese and English from PubMed,Web of Science,Embase,CNKI,Wanfang Database,etc.from January 1,2010 to June 30,2022,with Chinese search terms including thymosin α1,Tα1,tuberculosis,diabetes,and the English search terms including Thymosin alpha 1,Tα1,Tuberculosis,Diabetes mellitus,Diabetes.he results of randomized controlled trial of pulmonary tuberculosis patients complicated with diabetes were collected,all the patients were treated with conventional hypoglycemic and anti-tuberculosis therapy combined with thymosin α1.Results:A total of 1117 references were retrieved,and 13 were ultimately included in the study;the 685 included patients were divided into the observation group(n=335,combined with thymosin α1)and the control group(n=350,conventional hypoglycemic and anti-tuberculosis treatment).Meta analysis showed that,of the observation group,the treatment efficacy rate(OR(95％CI)=4.08(2.77-6.02)),sputum negative conversion rate(OR(95％CI)=4.61(3.21-6.63)),and lesion absorption rate(OR(95％CI)=5.06(3.19-8.04))were significantly better than those of the control group;the CD4+T cell levels after treatment(standardized mean difference(SMD)=2.07,95％CI:1.37-2.77,P＜0.001)and CD3+T cell levels(SMD(95％CI)=2.33(0.98-3.67),P=0.001)were significantly better than those in the control group;after treatment,the CD8+T cell level was significantly lower than that in the control group(SMD(95％CI)=-2.21(-2.95--1.48),P＜0.001),and the CD4+/CD8+ratio was significantly increased(SMD(95％CI)=1.25(0.73-1.77),P＜0.001).Conclusion:Conventional hypoglycemic and anti-tuberculosis combination with thymosin α1 treatment for pulmonary tuberculosis patients complicated with diabetes could improve the treatment efficiency,focus absorption rate and sputum negative conversion rate;with the treatment,the patient's CD4+,CD34 T cell levels,and CD4+/CD8+ratio have all increased.关键词
结核,肺/糖尿病/胸腺激素类/治疗结果/Meta分析Key words
Tuberculosis,pulmonary/Diabetes mellitus/Thymus hormones/Treatment outcome/Meta-analysis分类
医药卫生
