国际神经病学神经外科学杂志2024，Vol.51Issue(1)：35-39,5.DOI:10.16636/j.cnki.jinn.1673-2642.2024.01.006
脑动脉粥样硬化性狭窄患者合并颅内动脉瘤的血流动力学特征及其危险因素研究
Hemodynamic characteristics of patients with cerebral atherosclerotic stenosis and intracranial aneurysm and related risk factors
年夫顺 1钟平 1朱刚 1张蕾 1马争飞 1薛庆华1
作者信息
- 1. 安徽医科大学附属宿州医院神经内科,安徽 宿州 234000
- 折叠
摘要
Abstract
Objective To investigate the hemodynamic characteristics of patients with cerebral atherosclerotic stenosis and intracranial aneurysm(IA)and related risk factors.Methods Clinical data were collected from 160 patients with cerebral atherosclerotic stenosis who were treated in Suzhou Hospital of Anhui Medical University from September 2019 to January 2023.Computed tomography angiography(CTA)and digital subtraction angiography(DSA)were performed for all patients.According to the imaging findings,the patients were divided into stenosis+IA group with 25 patients and stenosis group with 135 patients.Baseline data and hemodynamic parameters were compared between the two groups.A multivariate logistic regression analysis was used to investigate the risk factors for IA in patients with cerebral atherosclerotic stenosis,and a receiver operating characteristic(ROC)curve analysis was used to assess the value of wall shear stress(WSS)and oscillatory shear index(OSI)in predicting IA in these patients.Results The stenosis+IA group had significantly higher WSS and OSI than the stenosis group(P<0.05).Compared with the stenosis group,the stenosis+IA group had a significantly higher proportion of patients with smoking history,diabetes or hypertension(P<0.05).The multivariate logistic regression analysis showed that smoking history,diabetes,hypertension,WSS>0.450 Pa,and OSI>0.057 were risk factors for IA in patients with cerebral atherosclerotic stenosis(P<0.05).The ROC analysis showed that WSS and OSI could be used to predict IA in patients with cerebral atherosclerotic stenosis,with an area under the ROC curve of 0.857 and 0.784,respectively,a sensitivity of 0.681 and 0.859,respectively,and a specificity of 0.751 and 0.771,respectively(P<0.05).Conclusions Smoking history,diabetes,hypertension,WSS>0.450 Pa,and OSI>0.057 are risk factors for IA in patients with cerebral atherosclerotic stenosis,and WSS and OSI can be used to predict IA in these patients.关键词
脑动脉粥样硬化性狭窄/颅内动脉瘤/血流动力学特征/危险因素/CT血管成像Key words
cerebral atherosclerotic stenosis/intracranial aneurysm/hemodynamic characteristics/risk factors/CT angiography分类
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年夫顺,钟平,朱刚,张蕾,马争飞,薛庆华..脑动脉粥样硬化性狭窄患者合并颅内动脉瘤的血流动力学特征及其危险因素研究[J].国际神经病学神经外科学杂志,2024,51(1):35-39,5.
