国际神经病学神经外科学杂志2024，Vol.51Issue(1)：40-43,4.DOI:10.16636/j.cnki.jinn.1673-2642.2024.01.007
丙戊酸镁联合拉莫三嗪用于难治性癫痫所致精神障碍患者的疗效观察
Therapeutic effects of magnesium valproate plus lamotrigine in patients with mental disorders due to refractory epilepsy
摘要
Abstract
Objective To explore the therapeutic effects of magnesium valproate plus lamotrigine in patients with mental disorders due to refractory epilepsy.Methods A total of 120 patients with mental disorders due to refractory epilepsy treated in the Xi'an North Hospital from January 2020 to January 2022 were included in this study.These patients were divided into control group(59 patients)and test group(61 patients).The control group received magnesium valproate,and the test group received magnesium valproate plus lamotrigine.The two groups were compared for response rate and expression of interleukin-1β(IL-1β)and interleukin-6(IL-6)in serum and tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2)IL-2 in peripheral blood.Results The overall response rate for epilepsy seizure was significantly higher in the test group than in the control group(93.4％vs 81.4％,P<0.05).The overall response rate for mental disorders was significantly higher in the test group than in the control group(98.4％vs 72.9％,P<0.05).At 1 month after treatment,the expression levels of IL-1β,IL-6,TNF-α,and IL-2 were significantly lower in the test group than in the control group(P<0.05).Conclusions Magnesium valproate plus lamotrigine is effective in treating mental disorders due to refractory epilepsy and effectively regulates the expression of IL-1β and IL-6 in serum and IL-2 and TNF-α in peripheral blood.关键词
难治性癫痫/丙戊酸镁/拉莫三嗪/白细胞介素-1β/白细胞介素-6/肿瘤坏死因子-α/白细胞介素-2Key words
refractory epilepsy/magnesium valproate/lamotrigine/interleukin-1β/interleukin-6/tumor necrosis factor-α/interleukin-2分类
医药卫生引用本文复制引用
姬金花,刘峰昌,王飞娟,师媛,范凯..丙戊酸镁联合拉莫三嗪用于难治性癫痫所致精神障碍患者的疗效观察[J].国际神经病学神经外科学杂志,2024,51(1):40-43,4.基金项目
陕西省教育厅2021年度青年创新团队建设科研计划项目(21JP012). （21JP012）
