国际神经病学神经外科学杂志2024，Vol.51Issue(1)：59-66,8.DOI:10.16636/j.cnki.jinn.1673-2642.2024.01.011
SOX9在神经胶质瘤中的作用研究进展
Research advances in the role of SOX9 in glioma
王旭东 1梁强 2周景寰 1王鸿宇 1潘亚文3
作者信息
- 1. 兰州大学第二临床医学院,甘肃 兰州 730030||兰州大学第二医院神经病学研究所,甘肃 兰州 730030
- 2. 兰州大学第二医院神经外科,甘肃 兰州 730030||兰州大学第二医院神经病学研究所,甘肃 兰州 730030
- 3. 兰州大学第二临床医学院,甘肃 兰州 730030||兰州大学第二医院神经外科,甘肃 兰州 730030||兰州大学第二医院神经病学研究所,甘肃 兰州 730030
- 折叠
摘要
Abstract
The transcription factor SOX9 belongs to the SOXE subclass of the SOX family,and a large number of articles have shown that the expression of SOX9 is associated with glioma.Glioma is the most common malignant brain tumor,and patients with high-grade glioma have an extremely poor prognosis;therefore,it is very important to investigate the pathogenesis of glioma and find new effective therapeutic targets.The transcription factor SOX9 regulates downstream targets through a variety of signaling pathways,thereby affecting the development,progression,treatment,and prognosis of glioma.The upregulation of SOX9 is positively correlated with the progression of glioma,which is unfavorable to the prognosis of glioma,and the reduction in SOX9 expression may be beneficial to the treatment of glioma.Meanwhile,various microRNAs indirectly affect the progression of glioma by downregulating the expression of SOX9.This article reviews the structure and function of SOX9 and the signaling pathways and mechanisms of its effect on glioma cell phenotype and looks forward to the potential therapeutic targets in the future.关键词
神经胶质瘤/SOX9/微小RNAKey words
glioma/SOX9/microRNA分类
医药卫生引用本文复制引用
王旭东,梁强,周景寰,王鸿宇,潘亚文..SOX9在神经胶质瘤中的作用研究进展[J].国际神经病学神经外科学杂志,2024,51(1):59-66,8.
