国际神经病学神经外科学杂志2024，Vol.51Issue(1)：74-78,5.DOI:10.16636/j.cnki.jinn.1673-2642.2024.01.013
靶向铁死亡药物治疗创伤性颅脑损伤的研究进展
Research advances in pharmacotherapy targeting ferroptosis in treatment of traumatic brain injury
摘要
Abstract
Traumatic brain injury(TBI)is a type of mechanical injury caused by the impact of external force,including primary and secondary injuries.Pharmacotherapy that inhibits cell death due to secondary injury is of great significance for improving the prognosis and quality of life of TBI patients.Ferroptosis is the process of programmed cell death induced by iron-dependent lipid peroxidation and is involved in the physiological and pathological regulation of a variety of acute and chronic nervous system diseases.Studies have shown that ferroptosis is involved in the mechanism of neuronal death due to TBI secondary injury and is associated with long-term prognosis after TBI.This article summarizes the potential drugs targeting ferroptosis for the treatment of TBI patients,and targeted and precise intervention strategies are adopted for TBI to prevent the ferroptosis of nerve cells after secondary TBI injury,protect nervous tissue,and reduce the disability and mortality rates of patients.关键词
创伤性脑损伤/铁死亡/药物治疗/神经元Key words
traumatic brain injury/ferroptosis/pharmacotherapy/neuron分类
医药卫生引用本文复制引用
岳海云,徐广振..靶向铁死亡药物治疗创伤性颅脑损伤的研究进展[J].国际神经病学神经外科学杂志,2024,51(1):74-78,5.基金项目
山东省医药卫生科技项目(202304041700) （202304041700）
解放军第九六〇医院青年基金面上项目(2023MS04). （2023MS04）
