国际神经病学神经外科学杂志2024，Vol.51Issue(1)：79-85,7.DOI:10.16636/j.cnki.jinn.1673-2642.2024.01.014
重症肌无力的动物模型研究进展
Advances in the research on animal models for myasthenia gravis
摘要
Abstract
The animal models for myasthenia gravis(MG)have become a research hotspot in recent years.While various experimental models partially capture the heterogeneity of MG,due to their respective limitations,it is difficult to achieve a comprehensive emulation of all facets of MG.The experimental autoimmune myasthenia gravis(EAMG)model covers the key cellular mechanisms involved in the immune response against acetylcholine receptor,which provides a basis for understanding the immunological characteristics of MG.The passive transfer model is characterized by simple disease induction,rapidly manifesting the symptom of weakness within 24 hours after a single antibody injection.Genetic engineering models offer more specificity and can accurately simulate the genetic basis of MG,thereby making up for the shortcomings of the EAMG model.Drug-induced models attract researchers with their rapid modeling and do not involve complex immune activation and antigen induction,but with certain limitations in simulating disease complexity.By matching the phenotypes and functional responses of patient serum,the in vitro model allows a more intuitive observation of the role of heterologous cells in disease development,which is closer to clinical reality.This article summarizes the advantages and disadvantages of various experimental models and helps researchers to select the models suitable for different research purposes.This review provides directions for a deeper understanding of the complex mechanisms of this disease,as well as a scientific basis for the development of new therapeutic strategies.关键词
重症肌无力/动物模型/研究进展Key words
myasthenia gravis/animal model/research advances分类
医药卫生引用本文复制引用
姚舜禹,薛雅慧,杜妙乔,刘澍,彭永..重症肌无力的动物模型研究进展[J].国际神经病学神经外科学杂志,2024,51(1):79-85,7.基金项目
株洲市科技局课题(2021-009) （2021-009）
湖南中医药高等专科学校附属第一医院优秀科研创新团队(B2021-003) （B2021-003）
2022年湖南中医药大学校院联合基金项目(2022-44) （2022-44）
湖南省卫生健康委科研计划课题(C202303076574). （C202303076574）
