四川大学学报（医学版）2024，Vol.55Issue(2)：249-255,7.DOI:10.12182/20240360201
氧化应激对线粒体功能及椎间盘细胞的影响
Effects of Oxidative Stress on Mitochondrial Functions and Intervertebral Disc Cells
摘要
Abstract
Intervertebral disc degeneration is widely recognized as one of the main causes of lower back pain.Intervertebral disc cells are the primary cellular components of the discs,responsible for synthesizing and secreting collagen and proteoglycans to maintain the structural and functional stability of the discs.Additionally,intervertebral disc cells are involved in maintaining the nutritional and metabolic balance,as well as exerting antioxidant and anti-inflammatory effects within the intervertebral discs.Consequently,intervertebral disc cells play a crucial role in the process of disc degeneration.When these cells are exposed to oxidative stress,mitochondria can be damaged,which may disrupt normal cellular function and accelerate degenerative changes.Mitochondria serve as the powerhouse of cells,being the primary energy-producing organelles that control a number of vital processes,such as cell death.On the other hand,mitochondrial dysfunction may be associated with various degenerative pathophysiological conditions.Moreover,mitochondria are the key site for oxidation-reduction reactions.Excessive oxidative stress and reactive oxygen species can negatively impact on mitochondrial function,potentially leading to mitochondrial damage and impaired functionality.These factors,in turn,triggers inflammatory responses,mitochondrial DNA damage,and cell apoptosis,playing a significant role in the pathological processes of intervertebral disc cell degeneration.This review is focused on exploring the impact of oxidative stress and reactive oxygen species on mitochondria and the crucial roles played by oxidative stress and reactive oxygen species in the pathological processes of intervertebral disc cells.In addition,we discussed current cutting-edge treatments and introduced the use of mitochondrial antioxidants and protectants as a potential method to slow down oxidative stress in the treatment of disc degeneration.关键词
氧化应激/活性氧/线粒体功能/椎间盘细胞/综述Key words
Oxidative stress/Reactive oxygen species/Mitochondrial function/Intervertebral disc cells/Review引用本文复制引用
周豪,陈涛,吴爱悯..氧化应激对线粒体功能及椎间盘细胞的影响[J].四川大学学报（医学版）,2024,55(2):249-255,7.基金项目
国家自然科学基金项目面上项目(No.82272555)、浙江省基础公益基金项目(No.LGF21H060010)、浙江省卫生医药科技计划项目(No.2022PY071)和温州市重大创新攻关科技创新项目(No.ZY2022010)资助 （No.82272555）
