四川大学学报（医学版）2024，Vol.55Issue(2)：475-481,7.DOI:10.12182/20240160102
细胞脂滴在口腔疾病中的研究进展
Research Progress of Cellular Lipid Droplets in Oral Diseases
摘要
Abstract
Lipid droplets are dynamic multifunctional organelles composed of a neutral lipid core and a phospholipid monolayer membrane modified by a specific set of proteins.PAT family proteins are the most characteristic lipid droplet proteins,playing an important role in regulating lipid droplet structure,function,and metabolism.The biogenesis of lipid droplets involves neutral lipid synthesis and the nucleation,budding,and growth of the lipid droplets.Lipid droplets not only serve as the energy metabolism reserve of cells but also participate in intracellular signal transduction and the development of inflammation and tumor.Lipid droplets are closely connected to and interact with various organelles,regulating the division,the transportation,and the genetics of organelles.The complexity of lipid droplets biogenesis and the diversity of their functions may have provided a physiological basis for the pathogenesis and development of diseases,but further research is needed in order to better understand the relevant processes.Published findings have helped elucidate the association between lipid droplets and diseases,such as obesity,non-alcoholic fatty liver disease,neurodegenerative disease,cancer,and cardiovascular disease,but the relationship between lipid droplets and oral diseases has not been fully studied.Topics that warrant further research include the role and mechanisms of lipid droplets in the pathogenesis and development of oral diseases,the relationship between oral diseases and systemic diseases,and translation of the effect of lipid droplets on oral diseases into valuable clinical diagnostic and treatment methods.Herein,we reviewed the biogenesis and functions of lipid droplets and the progress in research concerning lipid droplets in oral diseases,including mouth neoplasms,periodontitis,and dental caries.关键词
脂滴/口腔肿瘤/牙周炎/龋病/综述Key words
Lipid droplets/Mouth neoplasms/Periodontitis/Dental caries/Review引用本文复制引用
徐思群,魏洁雅,谢静..细胞脂滴在口腔疾病中的研究进展[J].四川大学学报（医学版）,2024,55(2):475-481,7.基金项目
国家自然科学基金(No.81771047)和四川省科技创新人才项目(No.2022JDRC0044)资助 （No.81771047）
