环境与职业医学2024，Vol.41Issue(3)：335-341,7.DOI:10.11836/JEOM23278
DNA羟甲基化在砷暴露所致健康效应中的作用及机制研究进展
Research progress on roles and mechanisms of DNA hydroxymethylation in health effects in-duced by arsenic exposure
摘要
Abstract
Arsenic,a naturally occurring metal-like chemical element,is one of the 10 chemicals of major public concerns listed by the World Health Organization as harmful to the environment and human health.It can enter the human body through breathing,intaking food,drinking water,skin expo-sure,and other ways,and long-term exposure to arsenic can cause cancer of multiple organs and impaired function of multiple systems.Epigenetic mechanisms play an important role in ar-senic-induced health effects,and research suggested that the carcinogenicity of arsenic may be associated with epigenetic changes.Previous studies focused on the effects of arsenic on DNA methylation modification.In recent years,research showed that 5-hydroxymethylcytosine(5-hmC),an intermediate of active demethylation of DNA,can act as a sensitive epigenetic mark and play a crucial role as a"bridge"between arsenic exposure and health effects.Based on the latest research progress on the role of DNA hydroxymethylation in the health effects associated with arsenic exposure,this article briefly described the relationship between the health effects of arsenic exposure and DNA hydroxymethylation,summarized the possible mechanisms of DNA hydroxymethylation in the health effects associated with arsenic exposure,and provided a scien-tific basis for preventing and treating the health effects associated with arsenic exposure.关键词
5-羟甲基胞嘧啶/表观遗传/砷/健康效应/作用机制Key words
5-hydroxymethylcytosine/epigenetics/arsenic/health effect/mechanism of action分类
医药卫生引用本文复制引用
吴京京,宋杨,吴威,李淑祺,王莉军,王烁..DNA羟甲基化在砷暴露所致健康效应中的作用及机制研究进展[J].环境与职业医学,2024,41(3):335-341,7.基金项目
浙江省自然科学基金项目(LGD19H260001,LTGD23H260001) This study was funded. （LGD19H260001,LTGD23H260001）
