环境与职业医学2024，Vol.41Issue(3)：342-347,6.DOI:10.11836/JEOM23264
类脑器官在环境毒理学中的应用
Application of brain organoids in environmental toxicology
摘要
Abstract
Since the 19th century,the emergence of model systems has helped researchers further understand cellular signaling pathways,identify potential drug targets,and conduct environmental toxicological studies.Exogenous chemicals,such as pollutants,drugs,and industrial chemicals,may affect brain biological processes and functions and eventually lead to neurological diseases.However,the brain is a complex and well-organized human organ,which is fundamentally different from any existing model system.Animal models may not be able to completely simulate the human brain in testing the neurotoxicity of environmental pollutants due to species differences.Human brain organoids,generated from human pluripotent stem cells,are emerging model systems for neurotoxicological research in line with the real situation of human body at the level of genome,transcriptome,and metabolome,and provide an effective platform for testing neurotoxicity of environmental toxins.We reviewed the latest development of brain organoids technology and its application in the evaluation of environmental neurotoxins,and provided new insights into the application of brain organoids in environmental neurotoxicology.关键词
人类脑器官/环境毒理学/神经毒理学Key words
human brain organoid/environmental toxicology/neurotoxicology分类
医药卫生引用本文复制引用
陈书进,颜崇淮..类脑器官在环境毒理学中的应用[J].环境与职业医学,2024,41(3):342-347,6.基金项目
国家自然科学基金面上项目(81973062) This study was funded. （81973062）
