临床小儿外科杂志2024，Vol.23Issue(3)：288-292,5.DOI:10.3760/cma.j.cn101785-202311050-017
NLRP3炎性小体在肺损伤中的研究进展
Research advances of NLRP3 inflammasome in lung injury
摘要
Abstract
Common in clinical practices,lung injury may be roughly divided into chronic and acute lung injuries according to the development course of the disease.Inflammatory factors play an important role in the occurrence and development of chronic and acute lung injuries.Some researchers have reported that nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3(NLRP3)inflammasome plays an important regulatory role.NLRP3 inflammasome is a high molecular protein complex located in cells.Respon-ding to endogenous danger signals and damage stimuli,it is an important component of respiratory immunity.However,excessive activation of NLRP3 inflammasome leads to pyroptosis.A subsequent release of inflammatory factors induce a complex cascade of lung inflammation and ultimately cause tissue injury and lung dysfunction.This review summarized the roles of NLRP3 inflammasome in lung tissue inflammatory injury.It was intended to provide more effective treatments and research rationales for clinical management of lung injury.关键词
NLRP3炎性小体/细胞焦亡/肺损伤Key words
NLRP3 inflammasome/Pyroptosis/Lung injury引用本文复制引用
范雨洁,屈双权..NLRP3炎性小体在肺损伤中的研究进展[J].临床小儿外科杂志,2024,23(3):288-292,5.基金项目
湖南省自然科学基金面上项目(2023JJ30325) General Project of Hunan Provincial Natural Science Foundation(2023JJ30325) （2023JJ30325）
