南京医科大学学报（自然科学版）2024，Vol.44Issue(4)：546-552,566,8.DOI:10.7655/NYDXBNSN230859
腺嘌呤核苷酸转位酶:生理功能及在疾病发生中的病理意义
Adenine nucleotide translocase:physiological functions and pathological significance in disease occurrence
摘要
Abstract
Adenine nucleotide translocases(ANTs)are crucial for mitochondrial integrity and bioenergetic metabolism.There are four isoforms of ANTs.Under physiological conditions,ANTs primarily engage in the exchange of adenosine diphosphate(ADP)and adenosine triphosphate(ATP)across mitochondrial membranes.ANT isoforms are also potentially significant components of the mitochondrial permeability transition pore(mPTP),contributing to processes such as cellular apoptosis and proton leakage.Impairment of ANTs leads to mitochondrial dysfunction,which holds significant pathological implications in metabolic diseases,cardiomyopathies,and cancer progression.This review summarizes recent advancements and knowledge regarding ANTs,aiming to offer new insights into potential therapeutic strategies targeting ANTs in diseases.关键词
腺嘌呤核苷酸转位酶/代谢性疾病/恶性肿瘤/心肌病/线粒体/ADP/ATP载体/腺嘌呤核苷酸载体Key words
adenine nucleotide translocase/metabolic disease/malignant tumor/cardiomyopathy/mitochondrial/ADP/ATP carrier/adenine nucleotide carrier分类
医药卫生引用本文复制引用
胡永灿,吕凌..腺嘌呤核苷酸转位酶:生理功能及在疾病发生中的病理意义[J].南京医科大学学报（自然科学版）,2024,44(4):546-552,566,8.基金项目
国家自然科学基金(81971495) （81971495）
