西南医科大学学报2024，Vol.47Issue(2)：111-116,6.DOI:10.3969/j.issn.2096-3351.2024.02.004
CXCL5在2型糖尿病与恶性肿瘤相关性研究进展
Research Progress of CXCL5 in the Correlation Between Type 2 Diabetes Mellitus and Malignant Tumor
摘要
Abstract
Diabetes mellitus(DM)and malignant tumor(MT)are two major diseases that affect human physical and mental health.Insulin resistance is the main pathogenesis of type 2 diabetes mellitus(T2DM).Macrophages play an important role in the tumor immune response and highly infiltrate and produce C-X-C motif chemokine ligand 5(CXCL5)in diabetic patients.Tumor-associated macrophages(TAMs)/M2 macrophages highly infiltrate and secrete CXCL5 in the tumor microenvironment(TME).CXCL5 can fur-ther regulate TME by promoting tumor angiogenesis and combining with its target gene,thus affecting the occurrence,development and prognosis of MT.In this paper,the molecular characteristics and related pathways of CXCL5 as well as the research progress of CXCL5 in the correlation between T2DM and MT were elaborated,looking forward to open up new ideas and methods for the clinical treatment of T2DM and MT and improving the outcome.关键词
CXCL5/2型糖尿病/恶性肿瘤/肿瘤相关巨噬细胞/肿瘤微环境Key words
CXCL5/Type 2 diabetes mellitus/Malignant tumor/Tumor-associated macrophages/Tumor microenvironment分类
医药卫生引用本文复制引用
贺阿敏,侯绍章..CXCL5在2型糖尿病与恶性肿瘤相关性研究进展[J].西南医科大学学报,2024,47(2):111-116,6.基金项目
宁夏回族自治区科技厅重点研发项目(2021BFH03002) （2021BFH03002）
