南京医科大学学报（自然科学版）2024，Vol.44Issue(4)：573-578,594,7.DOI:10.7655/NYDXBNSN230749
外泌体microRNA在糖尿病性心脏病中的研究进展
Research progress of exosome-derived microRNA in diabetic heart disease
摘要
Abstract
Exosome-derived microRNAs(miRNA)are a class of non-coding single-stranded RNA secreted by exosomes,which alter protein expression by inhibiting the translation of messenger RNA.In diabetes,alterations in the coding regions of genes lead to changes in miRNA expression.These variations induce a series of pathophysiological changes,such as oxidative stress,mitochondrial dysfunction,myocardial apoptosis and pyroptosis,vascular remodeling,and fibrosis,thereby participating in the occurrence and development of diabetic heart disease.This article reviews the characteristics of exosome-derived miRNAs and summarizes their roles and therapeutic potential in diabetic heart disease.关键词
糖尿病性心脏病/外泌体/微小核糖核酸Key words
diabetic heart disease/exosome/microRNA分类
医药卫生引用本文复制引用
孙玥,周奕廷,丁栩,郁志明..外泌体microRNA在糖尿病性心脏病中的研究进展[J].南京医科大学学报（自然科学版）,2024,44(4):573-578,594,7.基金项目
太湖人才计划高端人才(2020-THRC-GD-YZM) （2020-THRC-GD-YZM）
江苏省卫健委老年健康科研课题(LKM2023031) （LKM2023031）
新"三名"战略项目高端人才培育(2023XSMZL-GD-YZM-2023) （2023XSMZL-GD-YZM-2023）
