国际眼科杂志2024，Vol.24Issue(4)：567-571,5.DOI:10.3980/j.issn.1672-5123.2024.4.13
影响湿性年龄相关性黄斑变性治疗应答不良的相关因素研究进展
Research progress of related factors affecting poor response to wet age-related macular degeneration
摘要
Abstract
Wet age-related macular degeneration(wARMD)emerges as a primary contributor to irreversible vision impairment in the aging demographic.In clinical practice,anti-vascular endothelial growth factor(VEGF)therapies exhibit pronounced success in managing wARMD.However,in the actual clinical application,there are significant individual differences in the prognosis of anti-VEGF drug therapy,and some patients show poor response to the treatment,which may be related to the morphological differences of retinal layers in macular area,genetics,systemic conditions and other factors.It will help develop a more rational and individualized treatment plan to judge the prognosis of patients according to their different clinical manifestations in advance,so as to reduce overtreatment and the risk of retinal damage.In recent years,most studies on treatment response mainly focus on fundus morphology,genetics and so on.In this study,the relevant factors affecting adverse response to wARMD were reviewed,aiming to provide with more accurate treatment and prognostic monitoring programs for clinicians.关键词
湿性年龄相关性黄斑变性/光学相干断层扫描/血管内皮生长因子/不良应答/危险因素Key words
wet age-related macular degeneration/optical coherence tomography/vascular endothelial growth factor/poor response/risk factors引用本文复制引用
潘海涛,李瑞庄,张秋丽,陈旭然..影响湿性年龄相关性黄斑变性治疗应答不良的相关因素研究进展[J].国际眼科杂志,2024,24(4):567-571,5.基金项目
广东省医学科学技术研究基金(No.A2020591) Medical Science and Technology Research Foundation of Guangdong Province(No.A2020591) （No.A2020591）
