国际眼科杂志2024，Vol.24Issue(4)：572-576,5.DOI:10.3980/j.issn.1672-5123.2024.4.14
NLRP3炎症小体在葡萄膜炎中的研究进展
Research progress of NLRP3 inflammasome in the treatment of uveitis
周敏 1胡秋明2
作者信息
- 1. (530200)中国广西壮族自治区南宁市,广西中医药大学||(415700)中国湖南省桃源县中医医院眼科
- 2. (530000)中国广西壮族自治区南宁市,广西医大晶亮眼科医院
- 折叠
摘要
Abstract
The NLRP3 inflammasome is a cellular multimeric protein complex that plays a crucial role in inflammation and immune responses.It consists of three main components:Nod-like receptor protein 3(NLRP3),apoptosis-associated speck-like protein containing(ASC)and cysteine protease 1(caspase-1).Uveitis is a broad term encompassing a range of inflammatory diseases that primarily affect the iris,ciliary body,vitreous,retina and choroid.It is considered a major cause of blindness globally.Numerous studies have demonstrated the involvement of NLRP3 inflammasome in the onset and progression of uveitis,indicating its potential as a significant therapeutic target for uveitis in the future.This article provides an overview of the structure,biological functions and activation pathways of the NLRP3 inflammasome,as well as the current research progress on its association with different types of uveitis.Additionally,it discusses the application potential of the NLRP3 inflammasome in the treatment of uveitis.关键词
NLRP3炎症小体/激活通路/葡萄膜炎/Behcet病/Vogt-小柳原田综合征Key words
NLRP3 inflammasome/activation pathways/uveitis/Behcet's disease/Vogt-Koyanagi Harada Syndrome引用本文复制引用
周敏,胡秋明..NLRP3炎症小体在葡萄膜炎中的研究进展[J].国际眼科杂志,2024,24(4):572-576,5.
