国际眼科杂志2024，Vol.24Issue(4)：589-595,7.DOI:10.3980/j.issn.1672-5123.2024.4.18
m6 A甲基化修饰在眼科疾病中的研究进展
Research progress of m6 A methylation modification in ocular diseases
摘要
Abstract
N6-methyladenosine(m6 A),the most common,abundant,and conserved RNA modification in eukaryotic cells,regulates RNA splicing,stability,output,degradation and translation through m6 A methyltransferase,m6 A demethylase,and m6 A methylated binding proteins.Recent studies have found that abnormal m6A methylation may mediate a variety of pathological processes in eyes and participate in the occurrence and development of metabolic,inflammatory,degenerative ocular diseases and ocular tumors,such as diabetic retinopathy,cataract,age-related macular degeneration and uveal melanoma.This review aims to summarize the roles of m6A methylation modification in ocular cells and ocular diseases,elucidate the potential molecular mechanisms of m6 A methylation in ocular diseases,so as to encourage innovative approaches in the treatment of these ocular diseases.关键词
N6-甲基腺苷(m6A)/RNA甲基化/糖尿病视网膜病变/白内障/年龄相关性黄斑变性/葡萄膜黑色素瘤Key words
N6-methyladenosine(m6 A)/RNA methylation/diabetic retinopathy/cataract/age-related macular degeneration/uveal melanoma引用本文复制引用
薛愚愚,刘春梦,陈婕,叶河江..m6 A甲基化修饰在眼科疾病中的研究进展[J].国际眼科杂志,2024,24(4):589-595,7.基金项目
四川省中医药管理局科学技术研究专项课题(No.2023zd001,2023MS580) Special Scientific Research Project of Administration of Traditional Chinese Medicine of Sichuan Province(No.2023zd001,2023MS580) （No.2023zd001,2023MS580）
