兰州大学学报（医学版）2024，Vol.50Issue(1)：28-34,7.DOI:10.13885/j.issn.1000-2812.2024.01.005
幽门螺杆菌阴性的慢性萎缩性胃炎患者胃液微生物群特征分析
Characterization of gastric juice microbiota in Helicobacter pylori-negative patients with chronic atrophic gastritis
摘要
Abstract
Objective To explore the composition of the gastric juice microbiota in patients with Helicobacter pylori-negative chronic atrophic gastritis(CAGn),and to look for gastric juice microbiota that may be related to the occurrence of CAGn.Methods Forty-eight patients who underwent gastroscopy at the Surgical Endos-copy Center of the First Hospital of Lanzhou University from 2020 to 2021 were selected for the study,includ-ing 21 with Helicobacter pylori-negative chronic non-atrophic gastritis(CNAGn)and 27 with CAGn.Gastric juice samples were collected and the third-generation sequencing of the 16S rRNA was used to detect gastric microbial composition in the two groups.Results The average age of the CAGn group was significantly higher than that of the CNAGn group(52.33±12.20 vs.40.67±7.95,P = 0.000 4).There was no significant difference in the microbial α-and β-diversity and the overall microbiota composition between the two groups.The significance analysis of the differences between the two identified 11 genera having been significantly enriched in the CNAGn group and 2 genera significantly enriched in the CAGn group.Conclusion In this study,the differential non-Helicobacter pylori microbiota of CAGn patients was screened,which may provide a reference for the diagnosis and treatment of CAGn patients.关键词
慢性萎缩性胃炎/幽门螺杆菌/胃液微生物群/16S rRNA三代全长测序Key words
chronic atrophic gastritis/Helicobacter pylori/gastric juice microbiota/the third-generation se-quencing of the 16S rRNA分类
医药卫生引用本文复制引用
郗家慧,房广娟,马瑞霞,周瑞丽,聂蓬,白仲添..幽门螺杆菌阴性的慢性萎缩性胃炎患者胃液微生物群特征分析[J].兰州大学学报（医学版）,2024,50(1):28-34,7.基金项目
中央高校基本科研业务费专项基金资助项目(lzujbky-2021-ey06) （lzujbky-2021-ey06）
甘肃科技计划资助项目(23JRRA1491 （）
22JR5RH1035) （）
