兰州大学学报（医学版）2024，Vol.50Issue(1)：87-94,8.DOI:10.13885/j.issn.1000-2812.2024.01.013
特发性肺纤维化生物标志物研究进展
Research progress in biomarkers of idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis has poor prognosis and high mortality,and if not treated in time,the median survival period is only 2～3 years after diagnosis.The early symptoms of idiopathic pulmonary fibrosis patients are not obvious,and the diagnosis is often in the mid to late stage of the disease,which seriously affects the prognosis.Therefore,early diagnosis and treatment are particularly important.Biomarkers can play a role in assisting diagnosis,evaluating the condition and predicting prognosis.The paper summarized some of the currently identified biomarkers of idiopathic pulmonary fibrosis from three aspects:alveolar epithelial cell dysfunction,extracellular matrix remodeling and fibrosis and immune dysfunction based on the patho-genesis of idiopathic pulmonary fibrosis,with the hope of providing assistance for the early diagnosis and treatment of idiopathic pulmonary fibrosis and improving prognosis.关键词
特发性肺纤维化/生物标志物/肺泡上皮细胞/细胞外基质/免疫功能紊乱Key words
idiopathic pulmonary fibrosis/biomarker/lung epithelial cell/extracellular matrix/immune dys-function分类
医药卫生引用本文复制引用
陶会会,舒娟,黄丽惠,包海荣..特发性肺纤维化生物标志物研究进展[J].兰州大学学报（医学版）,2024,50(1):87-94,8.基金项目
国家重点研发计划精准医学研究专项资助项目(2016YFC0901100) （2016YFC0901100）
甘肃省科技计划资助项目(20JR10FA666) （20JR10FA666）
