品牌与标准化Issue(2)：11-13,3.DOI:10.3969/j.issn.1674-4977.2024.02.004
头孢他美钠对不同细菌感染小鼠的保护作用研究
Protective Effects of Cefetamet Sodium on Mice Infected with Different Bacteria
王丹 1林鹏 2刘蓉 1张鹏 1赵志龙 2王冬妍1
作者信息
- 1. 沈阳市食品药品检验所,辽宁 沈阳 110122
- 2. 辽宁省药品检验检测院,辽宁 沈阳 110036
- 折叠
摘要
Abstract
Objective:To study the protective effect of cefetamet sodium against bacterial infection in mice.Methods A total of 110 mice,weighing 18～22 g,were randomly divided into 11 groups.They were divided into negative control group,different concentrations of cefetamet sodium group(5 groups),different concentrations of cefotaxime sodium injection group(5 groups).Each mouse intraperitoneally injected 0.5 mL of 10-2 Staphylococcus aureus.The drug was given intravenously to different groups immediately after infection and again 6 hours later.The volume of the drug was 20 mL/kg BW.The mice were observed continuously for 14 days,and the death of the mice was recorded and the half effective dose(ED50)was calculated.The same method was used for Streptococcus pneumoniae,E.coli(10-2)and Pseudomonas aeruginosa(10-3)infections.Result:The 50%effective doses of ceftazidime sodium were 532.4 mg/kg、483.2 mg/kg、423.9 mg/kg、691.6 mg/kg respectively in mice infected with Staphylococcus aureus,Streptococcus pneumoniae,Escherichia coli and Pseudomonas aeruginosa.Conclusion:Under the experimental conditions,ceftaxime sodium injection has protective effect on mice infected with different bacteria.关键词
头孢他美钠/小鼠/细菌感染Key words
cefetamet sodium/mice/bacterial infection引用本文复制引用
王丹,林鹏,刘蓉,张鹏,赵志龙,王冬妍..头孢他美钠对不同细菌感染小鼠的保护作用研究[J].品牌与标准化,2024,(2):11-13,3.
