中医药治疗老年单纯收缩期高血压的临床研究结局指标分析OACSTPCD

[Objective]To sort out the evaluation indexes of randomized controlled trials(RCT)of traditional Chinese medicine(TCM)in the treatment of isolated systolic hypertension(ISH)in the elderly,and to construct the core index set of clinical trials of TCM in the treatment of ISH in the elderly.[Methods]PubMed,CoChrane library,Embase,CNKI database,Wanfang database,VIP database were searched for randomized controlled clinical trials of TCM combined with long-acting calcium antagonist(CCB)or renin-angiotensin-aldosterone system blocker(ACEI or ARB)in the intervention of ISH in the elderly.The retrieval time limit was from the establishment of the database to December 31,2019.[Results]38 RCTS were included,with a total of 2848 patients,involving 396 indicators.The top 16 indicators in frequency rank were as follows:Office systolic blood pressure(7.04%),antihypertensive effective rate(6.31%),TCM syndrome efficacy(6.31%),office diastolic blood pressure(5.56%),liver function(4.29%),renal function(4.29%),blood routine(4.04%),urine routine(3.79%),incidence of adverse reactions(3.54%),night average systolic blood pressure(3.28%),24-hour mean systolic blood pressure(3.03%),daytime mean systolic blood pressure(3.03%),TCM syndrome score(3.03%),office pulse pressure difference(2.78%),daytime mean diastolic blood pressure(2.78%)and night mean diastolic blood pressure(2.78%).[Conclusion]There are many problems in the selection of indicators for the treatment of ISH in the elderly with TCM,such as large differences,large differences in measurement time points of indicators,and lack of characteristics of TCM.It is necessary to accelerate the development of ISH in the elderly.Set of core metrics.